Breast Cancer Awareness Month: Delivering anti-cancer drugs through the ducts
Posted Oct 28 2011 4:12am
A trial of 17 breast cancerAbnormal, uncontrolled cell division resulting in a malignant tumour that may invade surrounding tissues or spread to distant parts of the body. patients found that delivering a chemotherapyThe use of chemical substances to treat disease, particularly cancer. drug directly into the nipple resulted in more drug remaining within the breast increasing efficiency.
By using a catheterA tube used either to drain fluid from the body or to introduce fluid into the body. placed into the nipple, formulations of breast cancer drugs can be infused into the breasts. The effectiveness of four anti-cancer drugs being administered in this way were examined and the researchers from John Hopkins Kimmel Cancer Center found that 5-flourouracil (5FU) in comparison to pegylated liposomal doxorubicin (PLD) shrank breast tumours efficiently and spared breast ducts from damage caused by other anti-cancer drugs which can destroy the ductal lining.
By delivering chemotherapy drugs via an intraductal route in comparison to intravenousWithin a vein. drug administration higher concentrations of the drugs are found in the breast reducing the quantities of drugs circulating in the bloodA fluid that transports oxygen and other substances through the body, made up of blood cells suspended in a liquid..