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Aarkstore enterprise---Molecular Diagnostics Markets

Posted Oct 26 2010 5:54am

Table of Contents :
1. Overview 9
1.1 Statement of Report 9
1.2 About This Report 9
1.3 Scope of the Report 9
1.4 Objectives 9
1.5 Methodology 10
1.6 Executive Summary 12

2. Introduction to Molecular Diagnostics and PCR Technology 15
2.1 Science Overview: Introduction to Genomics and Its Opportunity 15
2.2 Impact of the Human Genome Project on Molecular Diagnostics 17
2.3 Considerations for Molecular and Clinical Diagnosis 18
2.4 Molecular Diagnosis in the Post-Genomic Era 19
2.5 Advances in Molecular Diagnostics Technologies 20
2.6 Genetic Variability and Disease 22
2.7 Major Technology Platforms 22
2.7.1 Gene-based Amplification Technologies 23
2.7.2 Detection of Amplified Gene Products 23
2.7.3 Target-Based Gene Amplification 24
2.7.3.1 Polymerase Chain Reaction 24
2.7.3.2 Real-time PCR 25
2.7.3.3 Nucleic Acid Sequence-Based Amplification 26
2.7.4 Probe-Based Amplification 26
2.7.4.1 Ligase Chain Reaction 26
2.7.4.2 Strand Displacement Amplification 26
2.7.4.3 Qß-replicase Amplified Probe Assay 26
2.7.5 Signal-Based Amplification 27
2.7.5.1 Branched DNA (bDNA) 27
2.7.6 Other Gene Amplification Technologies 27
2.7.6.1 Immuno-PCR 27
2.7.6.2 Bio-Barcode Assay 27

3. Nucleic Acid Test Applications 29
3.1 Blood Testing and Infectious Diseases 30
3.1.1 Molecular Diagnostics Market 30
3.1.1.1 Methods for DNA Detection and Gene Sequencing 42
3.1.1.2 Products and Applications 43
3.1.1.3 Oncology 44
3.1.2 SNPs and Genes: Medical Utility (Clinical Applications) 44
3.1.2.1 Clinical Application Initiatives 46
3.1.2.2 A Sampling of Clinical Application Collaborations 47
3.1.2.3 Collaborative Relationships 49
3.2 Diagnostic Testing Using DNA 50
3.2.1 HIV 52
3.2.2 Hepatitis Serologic Markers and Nucleic Acid Testing 54
3.2.2.1 Hepatitis A Virus (HAV) 54
3.2.2.2 Hepatitis B Virus (HBV) 55
3.2.2.3 Hepatitis C Virus (HCV) 58
3.2.2.4 Hepatitis D Virus (HDV) 63
3.2.2.5 Hepatitis E Virus (HEV) 63
3.2.2.6 HBV/HCV Viral Load and Drug Resistance 63
3.2.3 Severe Acute Respiratory Syndrome (SARS) 65
3.2.3.1 New Approach to Diagnosing Avian Influenza 66
3.2.3.2 Microarray or DNA Chip-Based Tests 68
3.2.4 Cancer Detection Using PCR 69
3.2.4.1 Lung Cancer 69
3.2.4.2 Oral Cancer 70
3.2.4.3 Prostate Cancer 70
3.2.4.4 Chronic Myelogenous Leukemia 70
3.2.4.5 Malignant Gliomas 71
3.2.4.6 Colorectal Cancer 71
3.2.4.7 Breast Cancer 71
3.2.4.8 Bladder Cancer 71
3.2.5 Microbiology Testing 71
3.2.5.1 Chlamydia 72
3.2.5.2 Gonorrhea 72
3.2.5.3 Tuberculosis 72
3.2.5.4 Group B Streptococcus 75
3.2.5.5 Pathogenic Enteric Bacteria 77
3.2.5.6 Bordetella pertussis 78
3.2.5.7 Legionella Pneumophila 78
3.2.5.8 Peridontal Bacteria 78
3.2.5.9 Pneumocystis Carinii 78
3.2.5.10 Methicillin-resistant Staphylococcus Aureus 79
3.2.6 Blood Screening 79
3.3 SNPs in Clinical Diagnostics 84
3.3.1 Functional Genomics 88
3.3.2 Paternity Testing 88
3.4 Industrial Testing and Food Diagnostics 89
3.4.1 The Market 89
3.4.2 Detection of H. pylori by PCR 92
3.4.3 Detection of E. coli 0157 92
3.4.4 Detection of Enteric Viruses 92
3.5 Forensics Market 93
3.5.1 Isolation of DNA for PCR Profiling 94
3.5.2 Analysis by PCR-Based DNA Typing 95
3.5.3 Rapid Isolation of DNA for RFLP and PCR 95
3.5.4 DNA for PCR-STR Typing 95
3.6 Bioterrorism and Molecular Diagnostics 95
3.6.1 Introduction 95
3.6.1.1 Current Biological Threat Detection Systems 98
3.6.1.2 Use of DNA Microarrays and Biochips for Gene Expression Profiles in BWA 99
3.6.1.3 Advantages and Disadvantages of Host Gene Expression Profiling as a Biothreat Detection System 100
3.6.2 Biological Warfare Agents 101
3.6.2.1 Anthrax 101
3.6.2.2 Botulinum Toxin 102
3.6.2.3 Ricin 102
3.6.2.4 IVD Industry and Bioterrorism Preparedness 102
3.6.2.4.1 Brucellosis 102
3.6.2.4.2 Cholera 103

For more information please contact :

http://www.aarkstore.com/reports/Molecular-Diagnostics-Markets-1336.html

http://blogs.aarkstore.com/

From:Aarkstore Enterprise
Contact: Neel
Email: press@aarkstore.com
URL: www.aarkstore.com

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