A Nurr1-Knockout Mouse Model for Parkinson's Disease and Stem Cell Differentiation
Posted Jun 15 2010 5:00pm
Description of Invention: The researchers have generated Nurr1-knockout mice via genomic locus inactivation using homologous recombination.
Transcription factor Nurr1 is an obligatory factor for neurotransmitter dopamine biosynthesis in ventral midbrain. From a neurological and clinical perspective, it suggests an entirely new mechanism for dopamine depletion in a region where dopamine is known to be involved in Parkinson's disease. Activation of Nurr1 may be therapeutically useful for Parkinson's disease patients; therefore, the mice would be useful in Parkinson's disease research.
Additionally, Nurr1 has been shown to be critical for development of midbrain dopaminergic neurons, and thus may contribute to stem cell-based therapies for neurological disorders. Nurr1 is also important for osteoblast differentiation, suggesting a general role in stem cell differentiation and growth.
Research and drug testing for Parkinson's disease and other neurological disorders
Stem cell research relating to neurological and other disorders and bone formation
Inventors: No Inventor Information Available.
MK Lee, H Choi, M Gil, VM Nikodem. Regulation of osteoblast differentiation by Nurr1 in MC3T3-E1 cell line and mouse calvarial osteoblasts. J Cell Biochem. 2006 June 1 [Epub ahead of print, doi:10.1002/jcb.20990]. [ PubMed abs ]
J Jankovic, S Chen, WD Le. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog Neurobiol. 2005 Sep-Oct, 77(1-2):128-138. Epub 2005 Oct 21, doi:10.1016/j.pneurobio.2005.09.001. [ PubMed abs ]
Licensing Status: This technology is available under a Biological Materials License.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Research Tools and Materials Animal Model
For Additional Information Please Contact: No Licensing Specialist Information Available.