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What is the effect of an A and C mutation of the MTHFR and a COMT polymorphism on seizure meds?

Posted by Dan's Mom

My 27 year old son has the above genetic mutations.  He is also dealing with a seizure disorder.  I have read that these mutations affect seizures and seizure meds.  Could you please tell me how this works?  Do the mutations make the meds not work as well?
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