MIT team discovers new DNA modification in bacteria acting as DNA Bookmark
Posted Sep 29 2008 10:45pm
Researchers from MIT have discovered that bacterial genes, known as the dnd gene cluster, gives bacteria the ability to employ DNA modification by adding sulfur to the sugar-phosphate DNA backbone as a phosphorothioate,
The same method used in laboratories worldwide to modify synthetic oligonucleotide.Why would bacteria conserve this system which requires five enzymes, each with different co-factors?”
Peter Dedon says the modification system might serve as either protection against foreign (unmodified) DNA, or as a “bookmark” to assist with transcription or replication of DNA.