Have severe, bilateral cramps which travel from calves to thighs and quads. All or one area cramp and the cramps last for many days rendering it difficult to walk. I have been hospitalized for Rhabdo from the cramps (CPK of 3000 and then years later CPK of 10,000). Have a muscle biopsy scheduled. My neurologist is leaning toward a metabolic myopathy. Last few months cramps coincide with my period.