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Entire Genome Sequencing from Single Molecule DNA

Posted Jul 22 2008 8:23pm

Cambridge basedHelicos Bioscienceannounced the publication of a report inScienceMagazine demonstrating the first single molecule sequencing of an organism (M13 virus genome) examining more than 280,000 strands of captured DNA.

Helicos’ uses a proprietary form of sequencing-by-synthesis called True Single Molecule Sequencing(tSMS)™. Unlike other methods, the technique builds up the sequence of each strand of DNA one base at a time.

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