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DNA microarray–based analysis may be useful for assessing the risks and benefits of hormone therapy

Posted Sep 12 2008 4:39pm

Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis. The US FDa has apprved use of two new microarrays for clinical decision making. The US Food and Drug Administration (FDA) encourages the development of new technologies such as microarrays which may improve and streamline assessments of safety and the effectiveness of medical products for the benefit of public health. The FDA anticipates that these new technologies may offer the potential for more effective approaches to medical treatment and disease prevention and management. One of the new application for microarrays apart from use in cancer treatment could be in Hormone replacement therapy. A study has been publoished using microarrays to identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy. some of the other studies can be viewd at

http://www.biomedcentral.com/1741-7015/4/16

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1555602

Filed under: HRT, Hormone replacement and Genetics, Pharmacogenomics, SNP analysis, bioinformatics, custom microarray, drug development, drug discoverry, gene expression, genotyping, microarray, ocimum biosolutions, toxicogenomics, transgenomics

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