Imagine if you could predict who would get the nasty side effects of chemotherapy before giving it. We could then taper the chemotherapy giving less of a dose and achieve the same response. Well, the first part of that dream is here today. AtSt JudeChildren's Research Hospital they have been actively investigating pharmacogenomics and chemotherapy. In astudyto be released in the May 15th edition of Blood we have just that.
During consolidation phase the Reduce Folate Carrier polymorphism led to the GI side effects with a 10.4 odds ratio.
UGT1a1polymorphisms led tojaundiceas well as reduced clearance of an agent calledmethotrexate(a chemo drug) perhaps leading to increased toxicity as well
This is a major study, that has had some replication in one gene or another. But the compiling of these polymorphisms has not been done. Likely we will need one more round of evaluation. But after that...we could have a pharmacogenomic test for side effects.
The Gene Sherpa says: This is great, but how do we adjust the chemo to avoid these reactions. We will likely need an adjustment scale based on polymorphisms. AKA Personalized Medicine! I am certain St Jude's has this in the works. Let's keep our eyes peeled :)