Zscan4, a Therapeutic Target for Cancer, Regenerative Medicine and Aging
Posted Jun 13 2010 5:00pm
Description of Invention: This technology has broad potential for the development of therapeutics for cancer, diseases of aging, and regenerative medicine, and targets Zscan4, a gene that regulates telomere length and genomic stability in embryonic stem (ES) cells.
The ability to maintain genomic stability in ES cells and other stem cells is critical for the development of stem cell-based therapies; genomic stability and telomere length are also active areas of cancer and aging research. NIA investigators have discovered that the Zscan4 gene regulates telomere length and genomic stability in ES cells, and plays an essential role in early embryonic development; this activity is independent of telomerase activity. The investigators have shown that ablation of Zscan4 results in shortened telomere length and deterioration of the karyotype of ES cells, and that Zscan4 overexpression increases telomere length.
This technology discloses methods for increasing genome stability or increasing telomere length in an ES cell, and methods of treating a subject in need of ES cell therapy. Also disclosed are methods of promoting blastocyst outgrowth of embryonic stem cells, as well as Zscan4 expression vectors and methods of identifying stem cells expressing Zscan4.
Development of therapeutics for cancer treatment, aging, and regenerative medicine
Development of assisted reproduction technologies
Studies of early embryonic development
Development Status: In vitro and in vivo studies have been performed.
and foreign counterparts in Europe, Australia, Canada, and Japan
M Zalzman et al. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 2010 Mar 24; advance online publication [ doi 10.1038/nature08882 ]
G Falco et al. Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev Biol. 2007 Jul 15;307(2):539-550. [ PubMed: 17553482 ]
Licensing Status: Available for licensing.
Collaborative Research Opportunity: The National Institute on Aging, Laboratory of Genetics, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact Nicole Guyton, Ph.D. at 301-435-3101 or firstname.lastname@example.org for more information.
Portfolios: Cancer Cancer - Therapeutics Internal Medicine Internal Medicine - Diagnostics Internal Medicine - Therapeutics In-vitro Data
For Additional Information Please Contact: Tara Kirby Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: email@example.com Phone: 301-435-4426 Fax: 301-402-0220