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Why Proxeed is not useful in treating a low sperm count

Posted Feb 12 2010 10:27am

The man with a low sperm count presents a very frustrating problem for doctors. Not only is he frustrated that he is " shooting blanks " and cannot get his wife pregnant he also expects the doctor to provide a quick solution to his problem. Most men ( and their wives) naively think that the doctor will be able prescribe a medicine which will help him to increase his sperm count. After all,isn't a low sperm count a very common problem ? And hasn't medical technology advanced so much that we can treat cancers and heart disease ? So shouldn't treating a low sperm count be child's play ?

It is true that conventional treatment of male infertility in the past used a wide array of medicines to try to improve a low sperm count in the infertile man. These included : HMG and HCG injections; clomid; and testosterone. Unfortunatelynone of these work ! Sperm counts tend to vary widely on their own ( even when no treatment is being given); and many of these medicines would actually cause the count to drop rather than to improvejust adding to the patient's frustration !

The newest medicine on the block is Proxeed - and many websites and advertisements claim that Proxeed helps to treat male infertility.Howeverwhile Proxeed may increase sperm counts in selected men ( and reduce them in others) it hasn't been proven to be effective in increasing pregnancy rates.

But what about all the websites which extol the virtue of Proxeed ? Actuallyif you drill a bit deeperyou will find that this is all just very clever marketing. For examplelook at the page which talks about how great Proxeed is at http://www.malereproduction.com/04_proxeed.html . Here you have a respected doctor endorsing Proxeed - so it must be goodright ? Howeverif you scroll downyou will find the website is promoted by IHR.com - and if you go to the order page for Proxeedyou will find that Sigma-Tau HealthScience the manufacturer of Proxeed is an IHR.com sponsor ! This is slick and sneaky marketing at its best !

But if it's sold in the US as a drugthen it must be FDA approved - and doesn't the US FDA insist on clinical evidence before allowing the sale of Proxeed ? Doesn't the FDA have to verify all the claims the manufacturer makes ? Againthe answer is No ! Proxeed is sold as a dietary supplement - and if you read the fine print at the bottom of the Proxeed manufacturer's websiteit clearly says - *These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnosetreatcureor prevent any disease and is not designed to improve sperm quality that is already optimal.

Please note that even the manufacturer does not claim that Proxeed treats the disease of low sperm count ( oligospermia) ! All they say it does is that it improves "sperm health". This is a very clever term which they have coined - and not one you will find in any medical textbook at allbecause we really cannot test the health of the sperm. All we can do is test for sperm dysfunction at present ! This means they can make this claim - and get away with itbecause there's no way of challenging it !

What about the 2004 study which showed an increase in pregnancy rates ? One swallow does not make a summer - and it's quite remarkable that on one seems to have been able to duplicate these results in the last 5 years !

What about the fact that it is an antioxidant and reduces "reactive oxygen species" ? So what ? The bottom line is simple - does it improve pregnancy rates ? The sad truth is that there is no evidence that it works. Howeversince it's just a simple tabletand in any case it " does no harm"many doctors will prescribe it - and many patients will take them.

Many men will observe that their sperm count increases after taking Proxeed and they get very excited when this happens. Howeverdo remember that sperm counts fluctuate all the time - and often the increase is inspite of the medicinesnot because of it . In any casea sperm count is not like a bank account that you should get excited when it increases ! The end-point is not an increase in the sperm count or motility - it's a baby ! While Proxeed may improve sperm counts in some men on some occasionsdouble blind clinical trials have shown they do not help to improve pregnancy rates. This criticism is also true for the currently fashionable Proxeedwhich is being marketed very aggressively and cleverly in the USA.

The problem with the medical treatment of a low sperm count is that for most people it simply doesn't work. After allif the reason for a low sperm count is a microdeletion on the Y-chromosomethen how can medication help ? The very fact that there are so many ways of "treating" a low sperm count itself suggests that there is no effective method available. This is the sad state of affairs today and much needs to be learnt about the causes of poor production of sperm before we can find effective methods of treating it.

Howeverpatients want treatmentso there is pressure on the doctor to prescribeeven if he knows the therapy may not be helpful . When most patients go to a doctorthey expect that the doctor will prescribe a medicine and treat their problem. Since most people still believe there is a "pill for every ill"they expect that the doctor will give them a medicine ( or an injection) which will increase their sperm count. No patient ever wants to hear the truth that there is really no effective treatment available today for increasing the sperm count.

Since most doctors know thisthey are pressurised into prescribing Proxeed for these patientsbecause they do not want the patient to be unhappy with them. They are worried that if they do not fulfill the patient’s expectation of a prescriptionthe patient will desert themand go elsewherewhich is why they often do not tell the patient the complete truth. The doctor also remembers the occasional anecdotal successes (who come back for followup while the others desert the doctor and are lost to followup) is why patients with low sperm counts are put on every treatment imaginable - with little rational basis - Vitamin EVitamin Chigh-protein dietshoemeopathic pills and ayurvedic churans. Howeverthe very fact that there are hundreds of medicines itself proves that there is no medicine which works !

Many doctors justify their prescriptions by saying - " Anyway it can't hurt - and in any casewhat else can we do? " Howeverthis attitude can be positively harmful. It wastes timeduring which the wife gets olderand her fertility potential decreases. Patients are unhappy when there is no improvement in the sperm count and lose confidence in doctors. It also stops the patient from exploring effective modes of alternative therapy - such as In Vitro Fertilization and ICSI Today empiric therapy should be criticised unless it is used as a short term therapeutic trial with a defined end-point.

A word of warning. Medical treatment for male infertility does not have a high success rate and has unpleasant side effectsso don't take it unless your doctor explains his rationale. The treatment is best considered "experimental" and can be tried as a therapeutic trial. Make surehoweverthat semen is examined for improvement after three months and then decide whether you want to press on regardless.

It is worth emphasising how small the list for male infertility treatment is - especially as compared to female treatment. This simply reflects our ignorance about male infertility - we know very little about what causes itand our knowledge about how to treat it is even more pitiable !
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