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Why Antidepressants Don?t Work for Treating Depression

Posted Sep 16 2008 11:59pm 1 Comment

Here’s some depressing recent medical news: Antidepressants don’t work.

What’s even more depressing?

The pharmaceutical industry and Food and Drug Administration (FDA) have deliberately deceived us into believing that they DO work.

As a physician, this is frightening to me. Depression is among the most common problems seen in primary-care medicine and soon will be the second leading cause of disability in this country.

The study I’m talking about was published in a recent issue of “The New England Journal of Medicine.”

It found that drug companies selectively publish studies on antidepressants. They have published nearly all the studies that show benefit -- but almost none of the studies that show these drugs are ineffective. (1)

That warps our view of antidepressants, leading us to think that they do work. And it has fueled the tremendous growth in the use of psychiatric medications, which are now the second leading class of drugs sold, after cholesterol-lowering drugs.

And it’s even worse than it sounds, because the positive studies hardly showed benefit in the first place.

For example, 40 percent of people taking a placebo (sugar pill) got better, while only 60 percent taking the actual drug had improvement in their symptoms. Looking at it another way, 80 percent of people get better with just a placebo.

That leaves us with a big problem -- millions of depressed people with no effective treatments.

Let’s take a closer look at depression.

“Depression” is simply a label we give to people who have a depressed mood most of the time, have lost interest or pleasure in most activities, are fatigued, can’t sleep, have no interest in sex, feel hopeless and helpless, can’t think clearly, or can’t make decisions.

But that label tells us NOTHING about the cause of those symptoms.

In fact, there are dozens of causes of depression -- each one needing a different approach to treatment.

==> Depression is not one-size-fits-all.

But it’s very common.

Women have a 10 to 25 percent risk and men a 5 to 12 percent risk of developing severe major depression in their lifetime. (2)

One in ten Americans takes an antidepressant. The use of these drugs has tripled in the last decade, according to a report by the federal government. In 2006, spending on antidepressants soared by 130 percent.

But just because antidepressants are popular doesn’t mean they’re helpful.

Unfortunately, as we now see from this report in “The New England Journal of Medicine,” they don’t work and have significant side effects.

Most patients taking antidepressants either don’t respond or have only partial response.

In fact, success is considered just a 50 percent improvement in half of depressive symptoms. And this minimal result is achieved in less than half the patients taking antidepressants.

That’s a pretty dismal record. It’s only made worse by the fact that 86 percent of people taking antidepressants have one or more side effects, including sexual dysfunction, fatigue, insomnia, loss of mental abilities, nausea, and weight gain.

No wonder half the people who try antidepressants quit after 4 months.

Now I want to talk to you about the reasons why doctors and patients have been deceived by the “antidepressant hoax.”

==> Despite what we have been brainwashed to believe, depression is not a Prozac deficiency!

Drug companies are not forced to publish all the results of their studies. They only publish those they want to.

The team of researchers that reported their findings in “The New England Journal of Medicine” took a critical look at all the studies done on antidepressants, both published and unpublished.

They dug up some serious dirt.

The unpublished studies were not easy to find. The researchers had to search the FDA databases, call researchers, and hunt down hidden data under the Freedom of Information Act.

What they found was stunning.

After looking at 74 studies involving 12 drugs and over 12,000 people, they discovered that 37 of 38 trials with positive results were published, while only 14 of 36 negative studies were published.

And those that showed negative results were in the words of the researchers, “published in a way that conveyed a positive outcome.”

That means the results were twisted to imply the drugs worked when they didn’t.

This isn’t just a problem with antidepressants. It’s a problem with scientific research. Some drug companies even pay or threaten scientists to not publish negative results on their drugs.

So much for “evidence-based” medicine!

Most of the time, we only have the evidence that the drug companies want us to have. Both doctors and patients are deceived into putting billions of dollars into drug companies’ pockets, while leaving millions with the same health problems but less money.

The scientific trust is broken. What can we do?

Unfortunately, there is no easy answer.

But I do think Functional Medicine, on which my approach of UltraWellness is based, provides a more intelligent way of understanding the research.

Rather than using drugs to suppress symptoms, Functional Medicine helps us find the true causes of problems, including depression.

I see this in so many of the patients I have treated over the years. Just as the same things that make us sick also make us fat, the same things that make us sick also make us depressed.

==> Fix the causes of sickness -- and the depression takes care of itself.

Just look at these few cases:

A 23-year-old had been anxious and depressed most of her life and spent her childhood and adolescence on various cocktails of antidepressants.

Turns out, she suffered from food allergies that made her depressed. Food allergies cause inflammation, and studies now show inflammation in the brains of depressed people.

In fact, researchers are studying powerful anti-inflammatory drugs used in autoimmune disease such as Enbrel for the treatment of depression.

So after she eliminated her IgG or delayed food allergies, her depression went away, she got off her medication -- and she lost 30 pounds as a side effect!

Here’s another.

A 37-year-old executive woman struggled for more than a decade with treatment-resistant depression (meaning that drugs didn’t work), fatigue, and a 40-pound weight gain.

We found she had very high levels of mercury. Getting the mercury out of her body left her happy, thin, and full of energy.

A 49-year-old man with severe lifelong depression had been on a cocktail of antidepressants and psychiatric medication for years but still lived under a dark cloud every day, without relief.

We found he had severe deficiencies of vitamin B12, B6, and folate. After we gave him back those essential brain nutrients, he called me to thank me. Last year was the first year he could remember feeling happy and free of depression.

These are just a few of the dozens of things that can cause depression.

The roots of depression are found in the 7 keys to UltraWelless and the 7 fundamental underlying imbalances that trigger the body to malfunction.

As we now see, taking antidepressants is not the answer to our looming mental health epidemic.

We need different solutions. I am very excited about my next book, “The UltraMind Solution” (coming out next year), which will address this important topic.

In the meantime, here are a few things that account for a lot of depression -- and how to fix them.

  1. Try an anti-inflammatory elimination diet that gets rid of common food allergens (see “The UltraSimple Diet”)
  2. Check for hypothyroidism
  3. Treat vitamin D deficiency with at least 2,000 to 5,000 U a day of vitamin D3
  4. Take omega-3 fats in the form of 1,000 to 2,000 milligrams (mg) a day of purified fish oil. Your brain is made of up this fat.
  5. Take adequate B12 (1,000 micrograms, or mcg, a day), B6 (25 mg) and folic acid (800 mcg). These vitamins are critical for metabolizing homocysteine which can play a factor in depression.
  6. Get checked for mercury
  7. Exercise vigorously five times a week for 30 minutes. This increases levels of BDNF, a natural antidepressant in your brain.

These are just of few of the easiest and most effective things you can do to treat depression. But there are even more, which you can address by simply working through the 7 Keys to UltraWellness.

Now I’d like to hear from you…

Have you been diagnosed with depression?

How have antidepressants worked for you?

Do you plan to try any of the approaches mentioned here?

Please let me know your thoughts by leaving a comment.

To your good health,

Mark Hyman, M.D.

Comments (1)
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I was diagnosed with depression with anxiety 21 years ago. I was prescribed trazadone at the time and it worked very well ....for a while. I was told told I needed anti-depressants the rest of my life. As seems to be the case most often I eventually ended up trying various ones and ended up up a cocktail and felt drugged and unhappy. I didn't have the acute anxiety but I didn't really have much of anything for emotions except sad. At this point I was on cymbalta, trazadone and buspirone plus tramadol for pain. I went in to my psychiatrist with my bag of pills and told him I wanted off them all. I was on 12 meds treating various things that had arisen as a result of being on anti-depressants.

I was scared of withdrawing from cymbalta on my own because of the horror stories and so I went with to help me through it. I am down to half half the cymbalta I was at a month ago with no problems but some minor headaches and tummy troubles. I am also down on my trazadone and my buspirone and no problems there either. I quit taking 3 other prescription drugs as well. Eventually I will get off of it all and will resist Rx drugs if at all possible. I now eat a mostly organic diet, little red meat, no white sugar or white flour or MSG in any of its forms. When I deviate from my food plan and ingest garbage I usually pay for it.

I am going to bookmark your site and read more. I already take fish oil, vitamin D3, B-complex and additional B-12 plus other supplements as recommended by Point of Return. I plan to have my thyroid checked at my next complete physical which is this month. I have many of the symptoms of hypothyroidism but the T4 test has always been negative and the doctor doesn't want to do the other one. I am going to insist this time.

Thanks for the information you have here. I would advise any loved ones with depression to work hard at improving their diet and try many things before taking anti-depressants. I wish someone had told me more 21 years ago.

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