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What are the causes of Pulmonary hypertension?

Posted Sep 06 2010 12:00am

In the last citing I highlighted the diagnostic techniques that differentiate pulmonary hypertension and other associated diseases that show similar signs and symptoms that might confuse you and your physician. That I explained the diagnostics previously, you must be thinking of this important question that will be striking in your mind by now.

What actually causes pulmonary hypertension? As is the case in hypertension, pulmonary hypertension can be of two types on the basis of causes. The primary pulmonary hypertension is generally referred to as idiopathic because it occurs without an identifiable cause. This is quite an aggressive and a life threatening disease that generally affects the younger population. In spite of the fact that smooth muscle cells lining your arteries build up and causes arterial obstruction, the cause still remains a mystery.

A new discovery revealed a familial form of the primary pulmonary hypertension. Primary pulmonary hypertension will get you if you have a mutated gene called BMPR2. This is because it generally encodes for the receptor present on the surface of your cells and binds to the molecules of the TGF-beta or the transforming growth factor beta type II receptor group. Some changes occur when binding to receptors takes place, which then shunts down the interior of the cells where a series of biochemical reactions occur, ultimately affecting its behavior. Now when you have a mutated gene, this process seldom takes place. Although it may provide a genetic diagnosis it also promises a potential target for therapy if you have familial type of pulmonary hypertension

What other diseases can cause pulmonary hypertension? Pulmonary hypertension can also be a cause of other diseases of the heart and the lungs. This is the second type of pulmonary hypertension known as secondary pulmonary hypertension. The major diseases that you may have and which can result in associated pulmonary hypertension are of primarily of the cardiopulmonary origin. These include: * Chronic obstructive pulmonary disease (COPD) * Emphysema, * Failure of the left heart ventricle, * Recurrent pulmonary embolism that is caused by the blood clot traveling from the legs or pelvic veins obstructing the pulmonary arteries. Other than these cardiopulmonary diseases you may also be suffering from the following diseases that might result in pulmonary hypertension: * underlying diseases such as scleroderma * dermatomyositis * systemic lupus erythematosus * sarcoidosis * human immunodeficiency virus (HIV) * Advanced liver disease (also called porto-pulmonary hypertension).

Pulmonary hypertension can also be caused by chronic low blood oxygen levels as in some patients with sleep apnea or other long-standing (chronic) lung disease. Other conditions that may cause give you this disease are long-standing (chronic) lung disease or by sleep apnea that causes chronic low blood oxygen levels. Can drugs cause pulmonary hypertension? Yes of course there are many drugs that can cause this disease. These are dexfenfluramine (Redux) and Fen/Phen but fortunately these medications have seen been withdrawn from the market.

Some street drugs such as, cocaine and methamphetamines can cause severe pulmonary hypertension. So if you are an addict of such drugs you would probably be getting this rare disorder. Check out more on pulmonary hypertension at pharmacy online

About the Author
I am pharmacist by profession (doctor of pharmacy). Drugs have become increasingly complex and people are being prescribed often. online pharmacyhas changed our lives today now it is very easy to get medicine via pharmacy online. Now you can buy quality medicine through online pharmacy

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