Health knowledge made personal
Join this community!
› Share page:
Go
Search posts:

Vitamin D Protects Against Advance of Colon Cancer

Posted Sep 13 2011 10:12pm
Posted on 2011-09-13 06:00:00 in Cancer | GI-Digestive | Vitamins |
Vitamin D Protects Against Advance of Colon Cancer
Previous studies have indicated that Vitamin D exerts a protective effect against various types of cancer and Vitamin D3 (or cholecalciferol) and some of its derivatives have been shown to inhibit colon cancer.  Researchers at the Vall d'Hebron Institute of Oncology (VHIO; Spain), in collaboration with the Alberto Sols Institute of Biomedical Research (CSIC-UAB; Spain), have confirmed the pivotal role of vitamin D, specifically its receptor (VDR), in slowing down the action of a key protein in the carcinogenic transformation process of colon cancer cells. This protein, known as beta-catenin, which is normally found in intestinal epithelial cells where it facilitates their cohesion, builds up in large quantities in other areas of the cells when the tumor transformation begins. As a result of these changes, the protein is retained in the cell nucleus, where it facilitate the carcinogenic process, and this is the point at which vitamin D intervenes, or rather, the vitamin D receptor (VDR). The researchers then analyzed the effect of the VDR on human colon cancer cell cultures and observed that the concentration of the altered protein, beta-catenin, increased in cells without the VDR. These findings were repeated in the three types of colon cancer cells studied, and confirmed the results observed in the mice.  In two-thirds of advanced colon cancer tumors there was a lack of VDR in the cancer cells, suggesting that this loss may contribute to speeding up the growth of the tumor. 

Maria Jesus Larriba, Paloma Ordonez-Moran, Irene Chicote, Genesis Martin-Fernandez, Isabel Puig, Alberto Munoz, Hector G. Palmer. “Vitamin D Receptor Deficiency Enhances Wnt/[beta]-Catenin Signaling and Tumor Burden in Colon Cancer .” PLoS One, 15 Aug 2011.



  
View Current Anti-Aging Newsletter!
Spanish researchers confirm that a lack of vitamin D increases the aggressiveness of colon cancer.
People with Metabolic Syndrome (obesity, hypertension, diabetes, and hyperlipidemia) are at increased risk of developing open-angle glaucoma.
People who take antioxidant vitamin supplements may be at reduced risk of death due to cancer, as well as reduced risk of premature death in-general.
Revealing a new mechanism controlling ageing in white blood cells, discovery by UK scientists may herald innovative approaches to boost the immune system.
Four behaviors characteristic of the anti-aging lifestyle markedly slash the risks of death.
Watching TV for an average of six hours a day may shorten a person’s life expectancy by almost five years.
Regular exercise may help prevent inflammation-related brain damage characteristic in Alzheimer’s Disease.
Due to disease-related inflammation, people with rheumatoid arthritis (RA) are at an increased risk of death due to cardiovascular disease.
Adding various spices to a plain meal can significantly reduce post-meal insulin and triglyceride levels.
In a cancer treatment breakthrough University of Pennsylvania (US) researchers have shown remissions among a small groupp of lymphocytic leukemia (CLL) patients
September
16–18 Stem Cell Fellowship:
Module II
A4M Board Certification Exams offered at this venue

OCtober
21–23 Stem Cell Fellowship:
Module III
December
8–10 Stem Cell Fellowship:
Module IV
A4M Board Certification Exams offered at this venue
International Events

 
Post a comment
Write a comment: