Health knowledge made personal
Join this community!
› Share page:
Search posts:

Vitamin D May Help Clear Alzheimer’s Brain Plaques

Posted Apr 01 2012 10:11pm
Posted on 2012-03-29 06:00:00 in Alzheimer's Disease | Vitamins |

In follow-up to research demonstrating that specific types of immune cells in Alzheimer's patients may respond to therapy with vitamin D3 and curcumin, a chemical found in turmeric spice, by stimulating the innate immune system to clear amyloid beta, the main component of plaques associated with Alzheimer's Disease, University of California/Los Angeles (UCLA; California, USA) researchers have elucidated the intracellular mechanism for this process.  Previous work by the team, based on the function of Alzheimer's patients' macrophages, showed that there are at least two types of patients and macrophages: Type I macrophages are improved by addition of 1a,25–dihydroxyvitamin D3 and curcuminoids (a synthetic form of curcumin), while Type II macrophages are improved only by adding 1a,25–dihydroxyvitamin D3. Researchers found that in both Type I and Type II macrophages, the added 1a,25–dihydroxyvitamin D3 played a key role in opening a specific chloride channel called chloride channel 3 (CLC3), which is important in supporting the uptake of amyloid beta through the process known as phagocytosis. The scientists also found that 1a,25–dihydroxyvitamin D3 strongly helped trigger the genetic transcription of the chloride channel and the receptor for 1a,25–dihydroxyvitamin D3 in Type II macrophages. Transcription is the first step leading to gene expression. The mechanisms behind the effects of 1a,25–dihydroxyvitamin D3 on phagocytosis were complex and dependent on calcium and signaling by the MAPK pathway, which helps communicate a signal from the vitamin D3 receptor located on the surface of a cell to the DNA in the cell's nucleus. The study authors conclude that: “The structure-function results provide evidence that 1,25D3 activation of [vitamin D receptor]-dependent genomic and nongenomic signaling, work in concert to recover dysregulated innate immune function in [Alzheimer’s Disease].”

Mathew T. Mizwicki, Danusa Menegaz, Jun Zhang, Antonio Barrientos-Duran, Stephen Tse, Milan Fiala, et al.  “Genomic and Nongenomic Signaling Induced by 1[alpha],25(OH)2-Vitamin D3 Promotes the Recovery of Amyloid-[beta] Phagocytosis by Alzheimer’s Disease Macrophages.” J Alzheimer’s Disease, March 2012, 29(1): 51-62.

Consumption of blueberries, blackberries, and strawberries influence how neurons communicate, potentially preventing inflammation in the brain.
Resveratrol, a polyphenol found in wine, exerts anti-inflammatory properties that may lower the risk of airway obstruction in the lungs.
Potentially toxic chemicals linked to escalating rates of endocrine disruption-related disease are present in a broad array of consumer products, including cosm
UCLA (US) researchers have identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main comp
Dietary supplementation with retinol may slash skin cancer risk by as much as 40%.
The amino acid taurine may exert protective effects against coronary heart disease.
Two glasses of cranberry juice a day may reduce the propensity of endothelial cells to produce compounds that harden the arteries.
Lutein and zeaxanthin may reduce cataract risk.
New insights in to the biological pathway by which yoga may be effective for stress-related medical conditions including depression, anxiety, high blood pressur
Having diabetes for ten years or more triples the risk of an ischemic stroke.
Anti-Aging Therapeutics 13   View the Table of Contents
  Order the Book
  Order the eBook Anti-Aging Forum MLDP Anti-aging jobs Join A4M
238. Flextime & Telecommuting Promote Worker Health
Flexible working arrangements, such as flexitime (self-scheduled work shifts) and telecommuting (working from home), are becoming more commonplace in the US and other industrialized nations. Researchers from Durham University (United Kingdom) reviewed 10 controlled before-and-after studies involving 16,603 participants, which evaluated a variety of flexible working arrangements for the impact on employee health and wellbeing...
Post a comment
Write a comment:

Related Searches