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Vascular Status Predicts Cognitive Decline

Posted May 08 2013 10:09pm
Posted on May 7, 2013, 6 a.m. in Diabetes Brain and Mental Performance Cardio-Vascular Stroke

In that previous studies suggest that vascular disease may contribute to increased risk of accelerated cognitive decline in people with type 2 diabetes, Scottish researchers investigated whether stroke and subclinical markers of vascular disease may be predicative of the decline.  The Edinburgh Type 2 Diabetes Study (ET2DS) Investigators research group studied 831 men and women, ages 60-75 years, who participated in two study waves.  The team found that suffering a stroke was significantly associated with estimated lifetime cognitive decline.  Certain subclinical markers of vascular disease – namely, N-terminal probrain natriuretic peptide (NT-proBNP), ankle-brachial index (ABI), and carotid intima-media thickness (cIMT) – also were associated with cognitive decline over a 4-year period.  Observing that: “Stroke and subclinical markers of cardiac stress and generalized atherosclerosis are associated with cognitive decline in older patients with type 2 diabetes,” the study authors submit that: “Further investigation into the potential use of subclinical vascular disease markers in predicting cognitive decline is warranted.”

Feinkohl I, Keller M, Robertson CM, Morling JR, Williamson RM, Nee LD, McLachlan S, Sattar N, Welsh P, Reynolds RM, Russ TC, Deary IJ, Strachan MW, Price JF; On behalf of the Edinburgh Type 2 Diabetes Study (ET2DS) Investigators.  “Clinical and Subclinical Macrovascular Disease as Predictors of Cognitive Decline in Older Patients With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study.”  Diabetes Care. 2013 Apr 11.

  
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Tip #160 - Brew Better Health
Certain studies suggest that coffee mitigates disease by reducing inflammation in blood vessels and supporting the normal function of the blood vessel lining. Coffee also is a rich source of antioxidants and magnesium, nutrients that are key in maintaining cardiovascular and circulatory health.

Researchers from the Harvard School of Public Health (Massachusetts, USA) studied 20 years of data collected on 41,736 men who participated in the Health Professionals Follow-up Study, and 86,214 women involved in the Nurses’ Health Study. The team found that in general, regular coffee consumption was linked to a slightly lower risk of death from any cause, and from cardiovascular disease in particular. Among women, those who drank at least 2 to 3 cups per day were one-quarter to one-third less likely to die of heart problems or stroke than women who did not drink coffee. For men, a protective effect was seen when drinking 4 to 5 cups daily.

A team from the University of Kuopio (Finland) completed a 21-year long study involving 1,409 men and women, ages 65 to 79 years old at the study’s concluding point. The researchers found that those study subjects who drank 3 to 5 cups of coffee a day at midlife lowered their risk of dementia and Alzheimer’s Disease by 65%, as compared to those who drank no or a little coffee.

Opt for drip brewed coffee – the kind that uses a paper filter. Coffee beans contain cafestol, a very potent dietary cholesterol-elevating compound. Whereas paper filters remove much of the cafestol during the drip brew process, French press coffee, Turkish and Scandinavian preparations, and espresso retain very high levels of cafestol.

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