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Vaccine Peptide Derived from XAGE-1 to Prevent Tumor Growth

Posted Jun 15 2010 5:00pm

Description of Invention:
This invention describes a novel peptide derived from the protein XAGE-1 which is expressed specifically in cancer cells of prostate and breast cancer, as well as Ewing's sarcoma. This peptide is able to bind to human HLA-A2 molecules and to induce specific cytotoxic T lymphocyte response in vivo.

This peptide has therapeutic potential as an immunogen, and might induce cancer specific immune responses in cancer patients, which may cause regression of the cancer or prevent cancer metastasis.

Inventors:
Jay A Berzofsky (NCI)
Ira H Pastan (NCI)
Masaki Terabe (NCI)


Patent Status:
HHS, Reference No. E-090-2003/0
US, Application No. 10/582,703 filed 12 Jun 2006



Portfolios:
Cancer
Cancer - Therapeutics
In-vitro Data



For Additional Information Please Contact:
David Lambertson Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: lambertsond@mail.nih.gov
Phone: 301-435-4632
Fax: 301-402-0220


Ref No: 956

Updated: 06/2010

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