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Vaccine Adjuvant for Inducing Th17 Focused Response

Posted Aug 21 2013 8:00pm

Description of Invention:
Adjuvant selection can be critical to a vaccine's effectiveness. Ideally, an adjuvant will target and activate specific immune pathways to increase the magnitude of a response to the vaccine. A limited range of adjuvants are presently available for human clinical use; these primarily affect T helper cells 1 and 2 (Th1 and Th2). Currently, no adjuvants are approved for human use which primarily affect IL-17-producing T helper cells (Th17) cells. Th17 focused adjuvants may prove critical for developing operative vaccines against pathogens where Th17 activity is essential for protection. This technology relates to novel adjuvants activating either caspase-associated recruitment domain protein 9 (CARD9) or caspase 1 pathways, or a combination of the two; and methods for using these adjuvants for stimulating an immune response. These adjuvants induce Th17 focused stimulation, which may prove essential to development of effective vaccines against a range of pathogens including bacteria and fungi.

Applications:
Vaccine

Advantages:
Th17 skewing adjuvant

Development Status:
Early-stage

Inventors:
F. Alan Sher (NIAID)
Kevin Shenderov (NIAID)
Vincenzo Cerundolo (University of Oxford)
Gurdyal Besra (University of Birmingham)


Patent Status:
HHS, Reference No. E-089-2012/0
US, Application No. 61/709,713 filed 04 Oct 2012


Relevant Publication:
  1. Shenderov K, et al. [ PMID 23630357 ]


Collaborative Research Opportunity:
The National Institute of Allergy and Infectious Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. For collaboration opportunities, please contact Richard Kitei at 301-496-2644.


For Licensing Information Please Contact:
Edward (Tedd) Fenn
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: fennea@mail.nih.gov
Phone: 301-435-5031
Fax: 301-402-0220


Ref No: 2620

Updated: 08/2013

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