Use of Marrow-Derived Glial Progenitor Cells as Gene Delivery Vehicles into the Central Nervous System
Posted Feb 02 2012 7:00pm
Description of Invention: The present disclosure relates to a method of treating Parkinson's disease by transfecting bone marrow cells with glial cell line-derived neurotrophic factor (GDNF) using a retroviral vector, and then administering the transfected cells intravenously to a mammal. The results reported confirm that cells derived from the bone marrow can migrate into the brains of adult mice. The detection of marrow-derived cells in brains of adult mice within days of transplantation provides a method in which genetically altered hematopoietic cells could be used to treat acute diseases of the brain.
Applications: Gene therapy
Advantages: Greater therapeutic precision for gene therapy of CNS disease
In vivo data available (animal)
Inventors: Martin Eglitis (NINDS) Eva Merey (NINDS) M Maral M Mouradian (NINDS)
For Licensing Information Please Contact: Charlene Sydnor Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-4689 Fax: 301-402-0220