Health knowledge made personal
Join this community!
› Share page:
Search posts:

Use of Marrow-Derived Glial Progenitor Cells as Gene Delivery Vehicles into the Central Nervous System

Posted Feb 02 2012 7:00pm

Description of Invention:
The present disclosure relates to a method of treating Parkinson's disease by transfecting bone marrow cells with glial cell line-derived neurotrophic factor (GDNF) using a retroviral vector, and then administering the transfected cells intravenously to a mammal. The results reported confirm that cells derived from the bone marrow can migrate into the brains of adult mice. The detection of marrow-derived cells in brains of adult mice within days of transplantation provides a method in which genetically altered hematopoietic cells could be used to treat acute diseases of the brain.

Gene therapy

Greater therapeutic precision for gene therapy of CNS disease

Development Status:
  • Early-stage
  • In vivo data available (animal)

Martin Eglitis (NINDS)
Eva Merey (NINDS)
M Maral M Mouradian (NINDS)

Patent Status:
HHS, Reference No. E-082-1997/1
US, , Patent No. 7,022,321, Issued 04 Apr 2006

For Licensing Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4689
Fax: 301-402-0220

Ref No: 2358

Updated: 02/2012

Post a comment
Write a comment:

Related Searches