Use of Marrow-Derived Glial Progenitor Cells as Gene Delivery Vehicles into the Central Nervous System

Description of Invention:
The present disclosure relates to a method of treating Parkinson's disease by transfecting bone marrow cells with glial cell line-derived neurotrophic factor (GDNF) using a retroviral vector, and then administering the transfected cells intravenously to a mammal. The results reported confirm that cells derived from the bone marrow can migrate into the brains of adult mice. The detection of marrow-derived cells in brains of adult mice within days of transplantation provides a method in which genetically altered hematopoietic cells could be used to treat acute diseases of the brain.

Applications:
Gene therapy

Advantages:
Greater therapeutic precision for gene therapy of CNS disease

Development Status:

• Early-stage
• In vivo data available (animal)

Inventors:
Martin Eglitis (NINDS)
Eva Merey (NINDS)
M Maral M Mouradian (NINDS)


Patent Status:
HHS, Reference No. E-082-1997/1
US, , Patent No. 7,022,321, Issued 04 Apr 2006



For Licensing Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: sydnorc@mail.nih.gov
Phone: 301-435-4689
Fax: 301-402-0220


Ref No: 2358

Updated: 02/2012