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Use of Adenosine Agonists to Prevent Arterial Vascular Calcification Disorder

Posted Sep 19 2010 5:00pm

Description of Invention:
Scientists at the National Human Genome Research Institute (NHGRI) and the National Heart Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH) have discovered a genetic defect in the Ecto-5’-nucleotidase (NT5E) gene which results in Cluster of Differentiation 73 (CD73) deficiency that leads to a decrease in adenosine, and ultimately, an increase in vascular calcification. NT5E encodes CD73, an enzyme that converts adenosine monophosphate (AMP) to adenosine in the extracellular region of the vascular endothelium. Normally, extracellular adenosine binds to one of the several receptors on the surface decreasing the production of cyclic AMP (cAMP) resulting in an inhibition of vascular calcification.

The discovery of this genetic mutation leading to a decrease in adenosine provides a method of treating or preventing the disorder by using adenosine receptor agonists as therapeutic agents. Adenosine receptor agonists can be used to treat or prevent disorders associated with vascular and/or joint capsule calcification, including for example atherosclerosis, Monkeberg’s medial sclerosis, CD74 deficiency, Ehlers Danlos syndrome (EDS), Marfan/Loewe Dietz syndrome, fibromuscular dysplasia, Kawasaki syndrome, pseudoxanthoma elasticum, and premature placental calcification.

Treatment for vascular calcification disorder by using adenosine receptor agonist agents.

Development Status:

William A Gahl (NHGRI)
Thomas C Markello (NHGRI)
Shira G Ziegler (NHGRI)
Manfred Boehm (NHLBI)
Cynthia Hillaire (NHLBI)

Patent Status:
HHS, Reference No. E-094-2010/0
US, Application No. 61/319,336 filed 31 Mar 2010

Relevant Publication:
  1. C St. Hilaire, et al. NT5E Mutations are Associated with Arterial Calcifications. New Engl J Med., Submitted 2010.

Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The NHGRI is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize adenosine receptor agonist compounds for therapeutic use including as a treatment of certain common as well as rare vascular calcification-related disorders (see above Description of Invention). Please contact NHGRI Technology Development Coordinator Claire T. Driscoll at for more information.

Internal Medicine
Internal Medicine - Therapeutics

For Licensing Information Please Contact:
Steven Standley Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4074
Fax: 301-402-0220

Ref No: 2166

Updated: 09/2010

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