Uc Davis Researchers Develop New Drug Delivery System For Bladder Cancer Using Nanoparticles
Posted Oct 25 2012 10:01pm
A team of UC Davis scientists has shown in experimental mouse models that a new drug delivery system allows for administration of three times the maximum tolerated dose of a standard drug therapy for advanced bladder cancer, leading to more effective cancer control without increasing toxicity.
The delivery system consists of specially designed nanoparticles that home in on tumor cells while carrying the anti-cancer drug paclitaxel. The same delivery system also was successfully used to carry a dye that lights up on imaging studies, making it potentially useful for diagnostic purposes. The findings are published today in the journal Nanomedicine.
“We have developed a novel, multifunctional nanotherapeutics platform that can selectively and efficiently deliver both diagnostic and therapeutic agents to bladder tumors,” said Chong-Xian Pan, principal investigator of the study and associate professor of hematology and oncology at UC Davis. “Our results support its potential to be used for both diagnostic and therapeutic applications for advanced bladder cancer.”