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Treatment of Viral Infection by Blocking Interleukin-21

Posted Jun 05 2012 8:00pm

Description of Invention:
Blocking interleukin (IL-21) may be an effective method to treat or prevent various viral infections. In the course of an immune response to a virus, IL-21, produced primarily by CD4+ T cells, can inhibit or stimulate (regulate), immune cell function (B cells, T cells, natural killer cells, dendritic cells). IL-21 regulation may be either protective or pathological; autoimmune disease pathology has been associated with IL-21 promoted inflammation (in: type 1 diabetes, lupus, and multiple sclerosis). This technology describes methods of blocking IL-21 that may reduce damaging inflammatory responses during certain viral infections. Specifically, the absence of IL-21 during respiratory viral infection such as pneumonia virus infection actually prevents some of the pathogenic effects that may be promoted by IL-21. Methods for controlling IL-21 signaling may be used to treat to prevent many pathological effects of pneumonia viruses, and other viral infections.

Prevention and treatment of many pathological effects of viral infections, including pneumonia.

New method for treating viral infection pathology.

Development Status:
  • Early-stage
  • Pre-clinical
  • In vivo data available (animal)

Warren J Leonard (NHLBI)
Rosanne Spolski (NHLBI)

Patent Status:
HHS, Reference No. E-017-2012/0
US, Application No. 61/579,801 filed 23 Dec 2011

Relevant Publication:
  1. Spolski R, et al. [ PMID 22238461 ]

Collaborative Research Opportunity:
The NHLBI is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize treatment of viral infection by blocking Interleukin-21 (E-017-2012). For collaboration opportunities, please contact Vincent Kolesnitchenko, Ph.D. at .

For Licensing Information Please Contact:
Edward (Tedd) Fenn
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5031
Fax: 301-402-0220

Ref No: 2448

Updated: 06/2012

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