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Treatment of Viral Infection by Blocking Interleukin-21

Posted Jun 05 2012 8:00pm

Description of Invention:
Blocking interleukin (IL-21) may be an effective method to treat or prevent various viral infections. In the course of an immune response to a virus, IL-21, produced primarily by CD4+ T cells, can inhibit or stimulate (regulate), immune cell function (B cells, T cells, natural killer cells, dendritic cells). IL-21 regulation may be either protective or pathological; autoimmune disease pathology has been associated with IL-21 promoted inflammation (in: type 1 diabetes, lupus, and multiple sclerosis). This technology describes methods of blocking IL-21 that may reduce damaging inflammatory responses during certain viral infections. Specifically, the absence of IL-21 during respiratory viral infection such as pneumonia virus infection actually prevents some of the pathogenic effects that may be promoted by IL-21. Methods for controlling IL-21 signaling may be used to treat to prevent many pathological effects of pneumonia viruses, and other viral infections.

Applications:
Prevention and treatment of many pathological effects of viral infections, including pneumonia.

Advantages:
New method for treating viral infection pathology.

Development Status:
  • Early-stage
  • Pre-clinical
  • In vivo data available (animal)


Inventors:
Warren J Leonard (NHLBI)
Rosanne Spolski (NHLBI)


Patent Status:
HHS, Reference No. E-017-2012/0
US, Application No. 61/579,801 filed 23 Dec 2011


Relevant Publication:
  1. Spolski R, et al. [ PMID 22238461 ]


Collaborative Research Opportunity:
The NHLBI is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize treatment of viral infection by blocking Interleukin-21 (E-017-2012). For collaboration opportunities, please contact Vincent Kolesnitchenko, Ph.D. at kolesniv@nhlbi.nih.gov .


For Licensing Information Please Contact:
Edward (Tedd) Fenn
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: fennea@mail.nih.gov
Phone: 301-435-5031
Fax: 301-402-0220


Ref No: 2448

Updated: 06/2012

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