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Transmission-Blocking Vaccine Against Malaria (2)

Posted Feb 27 2011 7:00pm

Description of Invention:
A new immunovaccine directed against the Pfs25 antigen of Plasmodium falciparum offers to significantly enhance the development of an effective antimalarial vaccine. Previously, peptides derived from the sporozoite and asexual stage of the parasite have only been able to stimulate weak production of antibodies. This Pfs25 antigen, which is only expressed in the sexual reproductive stage of the parasite, stimulates strong antibody response; anti-Pfs25 antibodies have effectively blocked the transmission of infection in animal studies.

David C Kaslow (NIAID)

Patent Status:
HHS, Reference No. E-055-1991/0
US, , Patent No. 5,853,739, Issued 29 Dec 1998
HHS, Reference No. E-055-1991/0
PCT, Application No. PCT/US92/03579 filed 07 May 1992

Infectious Diseases
Infectious Diseases - Vaccines

For Licensing Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5018
Fax: 301-402-0220

Ref No: 1186

Updated: 02/2011

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