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Transmission-Blocking Vaccine Against Malaria (1)

Posted Feb 27 2011 7:00pm

Description of Invention:
A transmission blocking vaccine developed against malaria contains a recombinant virus, which encodes a unique portion of the sexual stage surface antigen of Plasmodium falciparum (referred to as Pfs25), or the Pfs25 protein purified from infected host cells. Mice inoculated with the recombinant virus developed antibodies capable of blocking transmission of the virus. None of the monoclonal antibodies known to block transmission recognize the reduced Pfs25 antigen. This vaccine, which induces high, long-lasting titers at low cost, can be useful for controlling malaria.

David C Kaslow (NIAID)

Patent Status:
HHS, Reference No. E-035-1991/0
US, , Patent No. 6,780,417, Issued 24 Aug 2004
HHS, Reference No. E-035-1991/0

Infectious Diseases
Infectious Diseases - Vaccines

For Licensing Information Please Contact:
Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5515
Fax: 301-402-0220

Ref No: 1185

Updated: 02/2011

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