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Transmission-Blocking Malaria Vaccine

Posted Jan 10 2013 7:00pm

Description of Invention:
There is no vaccine for malaria, and there is growing resistance to existing anti-malarial drugs. Sexual stage-specific antigens are of interest as vaccine candidates because disruption of these antigens would reduce the fertility and, thus, the infectivity of the parasite.

This invention claims methods and compositions for delivering a Plasmodium P47 vaccine or antibody to P47 to prevent Plasmodium falciparum or Plasmodium vivax malaria. P47 and other antigens have been mentioned as potential transmission-blocking vaccines due to their surface location on gametes. The gene for P47 antigens is also well characterized. Recent discoveries have noted that P47 allows the parasite to suppress or evade the immune system, thereby ensuring the mosquitoes' survival. Recent discoveries have also shown the mechanism by which P47 enables survival of the parasite by manipulation of the mosquito immune system. Based on the critical role of P47 antigens in transmission, the disruption of the function of P47 by various means can be an innovative and forceful means to control and/or reduce the prevalence of malaria.

Applications:
Malaria vaccine, diagnostic and therapeutic.

Advantages:
  • Single protein malaria transmission-blocking vaccine.
  • Cost-effective, simple manufacturing process for vaccine.
  • Potentially lower-cost malarial vaccine for developing/developed countries.


  • Development Status:
    • Pre-clinical
    • In vitro data available
    • In vivo data available (animal)


    Inventors:
    Carolina Barillas-Mury (NIAID)
    Alvaro Molina-Cruz (NIAID)


    Patent Status:
    HHS, Reference No. E-222-2012/0
    US, Application No. 61/684,333 filed 17 Aug 2012


    Relevant Publication:
    1. Molina-Cruz A, et al. [ PMID 22623529 ]


    Collaborative Research Opportunity:
    The National Institute of Allergy and Infectious Diseases (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize malaria vaccines, diagnostics and therapeutics. For collaboration opportunities, please contact Tristan J. Mahyera at tristan.mahyera@nih.gov or 301-827-0251.


    For Licensing Information Please Contact:
    Peter Soukas J.D.
    NIH Office of Technology Transfer
    6011 Executive Blvd. Suite 325 Room 14,
    Rockville, MD 20852-3804
    United States
    Email: soukasp@mail.nih.gov
    Phone: 301-435-4646
    Fax: 301-402-0220


    Ref No: 2506

    Updated: 01/2013

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