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Transforming Growth Factor Beta-1 (TGF-beta1) Transgenic Mouse Model

Posted Aug 16 2010 5:00pm

Description of Invention:
Transforming Growth Factor-beta1 (TGF-beta1) is a multifunctional cytokine that is involved in many physiological processes such as immune regulation, cell proliferation, angiogenesis, apoptosis, and extracellular matrix deposition. Overexpression of activated TGF-beta1 signaling pathway is known to play a role in many disease processes, such as inflammation, fibrosis and tumor metastasis.

NIH inventors have developed a transgenic mouse model, designated beta1glo, which permits conditional, gene-specific overexpression of TGF-beta1. The model features a TGF-beta1 transgene for which expression is blocked by a floxed enhanced green fluorescent protein (EGFP) gene downstream of the promoter. Excision of the EGFP gene by Cre recombinase allows expression of TGF-beta1. Thus, these mice may be cross-bred with a variety of Cre transgenic mouse lines in order to study the role of TGF-beta1 in targeted organ systems and tissues.

Inventors:
Ashok B Kulkarni (NIDCR)
Bradford E Hall (NIDCR)


Patent Status:
HHS, Reference No. E-016-2010/0

Research Tool -- patent protection is not being pursued for this technology

Relevant Publication:
  1. BE Hall, C Zheng, WD Swaim, A Cho, CN Nagineni, MA Eckhaus, KC Flanders, IS Ambudkar, BJ Baum, AB Kulkarni. Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest. 2010 Apr;90(4):543-555. [ PubMed: 20142803 ]


Licensing Status:
Available for licensing under a Biological Materials License.


Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Research Tools and Materials
Cancer
Cancer - Research Materials
Internal Medicine
Internal Medicine - Research Materials



For Licensing Information Please Contact:
Tara Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tk200h@nih.gov
Phone: 301-435-4426
Fax: 301-402-0220


Ref No: 2147

Updated: 08/2010

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