Transforming Growth Factor Beta-1 (TGF-beta1) Transgenic Mouse Model
Posted Aug 16 2010 5:00pm
Description of Invention: Transforming Growth Factor-beta1 (TGF-beta1) is a multifunctional cytokine that is involved in many physiological processes such as immune regulation, cell proliferation, angiogenesis, apoptosis, and extracellular matrix deposition. Overexpression of activated TGF-beta1 signaling pathway is known to play a role in many disease processes, such as inflammation, fibrosis and tumor metastasis.
NIH inventors have developed a transgenic mouse model, designated beta1glo, which permits conditional, gene-specific overexpression of TGF-beta1. The model features a TGF-beta1 transgene for which expression is blocked by a floxed enhanced green fluorescent protein (EGFP) gene downstream of the promoter. Excision of the EGFP gene by Cre recombinase allows expression of TGF-beta1. Thus, these mice may be cross-bred with a variety of Cre transgenic mouse lines in order to study the role of TGF-beta1 in targeted organ systems and tissues.
Research Tool -- patent protection is not being pursued for this technology
BE Hall, C Zheng, WD Swaim, A Cho, CN Nagineni, MA Eckhaus, KC Flanders, IS Ambudkar, BJ Baum, AB Kulkarni. Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest. 2010 Apr;90(4):543-555. [ PubMed: 20142803 ]
Licensing Status: Available for licensing under a Biological Materials License.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Research Tools and Materials Cancer Cancer - Research Materials Internal Medicine Internal Medicine - Research Materials
For Licensing Information Please Contact: Tara Kirby Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: email@example.com Phone: 301-435-4426 Fax: 301-402-0220