Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration
Posted Jun 15 2010 5:00pm
Description of Invention: These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.
Inventors: Katherine M Malinda (NIDCR) Hynda K Kleinman (NIDCR) Allan L Goldstein (EM)
This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).
Portfolios: Internal Medicine Internal Medicine - Therapeutics In-vivo Data
For Additional Information Please Contact: Surekha Vathyam Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-4076 Fax: 301-402-0220