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Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration

Posted Jun 15 2010 5:00pm

Description of Invention:
These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.

Katherine M Malinda (NIDCR)
Hynda K Kleinman (NIDCR)
Allan L Goldstein (EM)

Relevant Publication:
  1. This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).

Internal Medicine
Internal Medicine - Therapeutics
In-vivo Data

For Additional Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4076
Fax: 301-402-0220

Ref No: 31

Updated: 06/2010

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