Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration
Posted Jun 15 2010 5:00pm
Description of Invention: These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.
Inventors: Katherine M Malinda (NIDCR) Hynda K Kleinman (NIDCR) Allan L Goldstein (EM)
Relevant Publication:
This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).
Portfolios: Internal Medicine Internal Medicine - Therapeutics In-vivo Data
For Additional Information Please Contact: Surekha Vathyam Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: vathyams@mail.nih.gov Phone: 301-435-4076 Fax: 301-402-0220
Description of Invention:
These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.
Inventors:
Katherine M Malinda (NIDCR)
Hynda K Kleinman (NIDCR)
Allan L Goldstein (EM)
Relevant Publication:
Portfolios:
Internal Medicine
Internal Medicine - Therapeutics
In-vivo Data
For Additional Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: vathyams@mail.nih.gov
Phone: 301-435-4076
Fax: 301-402-0220
Ref No: 31
Updated: 06/2010