Thermophilus CRL 1190 fermented milk as gastritis treatment
Posted Apr 12 2010 12:00am
Gastritis produced by acetyl-salicylic acid (ASA, aspirin) consumption is a common disorder worldwide. The use of probiotics has been proposed to ameliorate different gastrointestinal tract diseases such as inflammatory bowel disease, diarrhea, irritable bowel syndrome, etc. However, little attention has been paid to the use of probiotics in gastric disease. The health-promoting effects ascribed to probiotic strains or fermented foods arise not only from bacteria themselves but also from the metabolites produced during fermentation such as exopolysaccharides (EPS). These polymers have been claimed to modulate the immune response and to display anti-ulcer activities.
A research article to be published on April 7, 2010 in the World Journal of Gastroenterology indicates that milk fermented with the probiotic Streptococcus thermophilus CRL 1190 was effective in the therapeutic treatment of chronic gastritis by modulating the immune response of the mice and by increasing the thickness of the gastric mucus gel layer. The fermented milk with S. thermophilus CRL 1190 (labelled FM 1190) decreased the pro-inflammatory cells that produce the cytokines TNF-α and gamma-interferon. TNF-α has been identified as an important mediator in NSAID-induced gastric mucosal damage.
Their findings are in line with a prior study that shows a protective benefit of whey protein concentrate on the ulcerative lesions resulting from administration of another NSAID, indomethacin.
The fermented milk showed a similar protective effect to omeprazole. The application of this fermented milk and/or its EPS constitutes a potential natural alternative for the prevention and treatment of ASA-associated gastric damage. The authors of this functional foods research article state that “the use of FM 1190 as a therapeutic agent constitutes a safe and nutritional alternative [to omeprazole] for gastritis treatment” (portions adapted from Eurekalert).
Reference: Rodríguez C, et al. Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis. World J Gastroenterol 2010; 16(13): 1622-1630
The full text of the research article is available online free here: