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Therapeutics for the Treatment and Prevention of Atherosclerosis and Cardiovascular Disease

Posted Jul 11 2010 5:00pm

Description of Invention:
This technology consists of peptides and peptide-analogues that enhance clearance of excess cholesterol in cells and do not exhibit the cytotoxicity that has hampered development of similar potential therapeutics.

Briefly, apolipoprotein A-1 (ApoA-1) promotes cholesterol efflux from cells and its concentration is inversely correlated with atherosclerotic events. The isolated peptidic component of ApoA-1 that acts within the cholesterol secretion pathway is therapeutic towards atherosclerosis but exhibits cytotoxic effects. In contrast, our inventors have derivatized that ApoA-1 peptide which is both less cytotoxic and more active than the underivatized component in initial studies. This potential therapeutic is similar to high density lipoprotein (HDL) therapy and may complement statin-mediated reduction of pro-atherogenic lipoproteins.

Applications:
  • Treatment and prevention of atherosclerosis
  • Treatment and prevention of cardiovascular disease, coronary artery disease, heart attack, stroke, and inflammation
  • Therapeutic or preventative coating for a heart or vascular implant
  • Alternative to HDL therapy


Advantages:
  • Enhanced cytotoxicity profile
  • Enhanced hydrophilicity profile
  • Complements statin-based therapies
  • Oral delivery approaches in development


Development Status:
Early stage with in vitro proof of concept data.

Inventors:
Amar A Sethi (NHLBI)


Patent Status:
HHS, Reference No. E-047-2009/0
US, Application No. 61/265,291 filed 30 Nov 2009


Licensing Status:
Available for licensing.


Portfolios:
Internal Medicine
Internal Medicine - Therapeutics



For Additional Information Please Contact:
Fatima Sayyid MHPM
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 21,
Rockville, MD 20852
United States
Email: Fatima.Sayyid@nih.hhs.gov
Phone: 301-435-4521
Fax: 301-402-0220


Ref No: 2129

Updated: 07/2010

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