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Therapeutic Approach for Autoimmune Diseases, Inflammatory Diseases and Cancers by Blocking CIKS-TRAF6 Interactions

Posted Mar 14 2011 8:00pm

Description of Invention:
CIKS (also known as Act1 or TRAF3IP2) is an intracellular adaptor protein involved in the signaling pathway of IL-17 cytokines. Interaction between CIKS and tumor necrosis factor receptor-associated factor (TRAF 6) is important for IL-17 signaling and collectively, IL-17, CIKS, and TRAF6 are involved in inflammatory responses associated with autoimmune diseases, inflammatory diseases, and cancers. Inhibition of CIKS activity has been shown to prevent and alleviate pathological symptoms in an animal model of rheumatoid arthritis and multiple sclerosis, and it is hypothesized that disruption of the interaction between CIKS and TRAF6 is a therapeutic strategy for the selective prevention of certain IL-17-mediated diseases.

NIAID investigators have discovered a short sequence within CIKS that is responsible for CIKS interaction with TRAF6. The disclosed sequence can be used to develop blocking peptides for the treatment of IL-17-mediated autoimmune diseases, inflammatory diseases, and cancers.

Applications:
Therapeutics for IL-17-mediated diseases, such as inflammatory diseases, autoimmune diseases, and cancer

Advantages:
Selective inhibition of CIKS-TRAF6 interactions

Development Status:
Basic research

Inventors:
Ulrich Siebenlist (NIAID)
Soeren U Soender (NIAID)
Sun Saret (NIAID)


Patent Status:
HHS, Reference No. E-268-2010/0
US, Application No. 61/418,782 filed 01 Dec 2010


Relevant Publication:
  1. Pisitkun P, et al. (2010) [ PubMed: 20662069 ]
  2. Claudio E, et al. (2009) [ PubMed: 19155511 ]


Licensing Status:
Available for licensing


Portfolios:
Cancer
Cancer - Therapeutics
Internal Medicine
Internal Medicine - Therapeutics



For Licensing Information Please Contact:
Tara Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tk200h@nih.gov
Phone: 301-435-4426
Fax: 301-402-0220


Ref No: 2236

Updated: 03/2011

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