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The Zinc Link

Posted Oct 26 2012 10:09pm

Previously, a number of studies have established that zinc is essential to protect against oxidative stress and help repair DNA damage. In zinc deficiency, the risk of which has been shown to increase with age, the body’s ability to repair genetic damage may be decreasing even as the amount of damage rises.  Emily Ho, from Oregon State University (Oregon, USA), and colleagues studied a lab animal model for the cellular zinc transport mechanisms.  Finding that zinc transporters were significantly dysregulated in old mice, the team observed that aged animals showed signs of zinc deficiency and displayed an enhanced inflammatory response even though their diet supposedly contained adequate amounts of zinc.    However, when researchers gave about 10 times the dietary requirement for zinc, the biomarkers of inflammation were restored to those of young animals.  Reporting that: “restoring zinc status via dietary supplementation reduced aged-associated inflammation,” the study authors submit that: “Our data suggested that age-related epigenetic dysregulation in zinc transporter expression may influence cellular zinc levels and contribute to increased susceptibility to inflammation with age.”

Wong CP, Magnusson KR, Ho E.  “Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation.”  J Nutr Biochem. 2012 Sep 13.

Oregon State University (US) team reveals the biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system
University of Illinois (US) researchers have developed a new imaging tool for physicians that fits in the palm of the hand and enables an array of diagnostics
Dietary supplementation of omega-3 fatty acids may lengthen telomeres and reduce oxidative stress.
Low serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 may correlate with Alzheimer's Disease, in men
A daily glass of polyphenol-rich apple juice decreases body fat, in obese men.
The fat- and sugar-rich Western diet leads to a lifetime of health problems, dramatically increasing the risk of stroke or death at a younger age.
Daily supplementation of pterostilbene, a potent antioxidant compound found abundantly in blueberries, lowers systolic and diastolic blood pressure.
Major changes to the profile of a person’s gut bacteria environment may associate with the development of type-2 diabetes.
A diet rich antioxidant vitamins helps to reduce the risk of heart attacks, in women.
Kansas State University (US) team has developed a simple blood test that can accurately detect the beginning stages of cancer.
An active lifestyle helps to reduce the risk of glaucoma, a leading cause of blindness around the world.
Researcher team from Britain and the United States find that people who leave education with fewer qualifications are prone to age more quickly.
University of Rochester (US) scientists discover how DNA maintenance is regulated, opening the door to interventions that may enhance the body’s natural preserv
Ensuring adequate intakes of selenium may reduce the risk of age-related diseases such as cancer and heart disease,
Polyphenols present in green tea exert a potent antioxidant effect that helps to counteract free radical damage to cells.
The "longevity" protein SIRT1, known for its life-spanning effects in different species, inhibits the development of a known precursor to prostate cancer
Slowing the activity of mitochondria promotes survival and enhances longevity, in a C. elegans (roundworm) model.
Whitehead Institute researchers show that the multi-component mechanistic target of rapamycin complex 1 (mTORC1) in mammals is involved in the aging process
Boston University School of Medicine (US) researchers uncover the interaction between T-cells and monocytes that promotes a pro-inflammatory response.
UCSD (US) researchers discover Sestrin, a protein that functions as natural inhibitor of aging and age-related pathologies in a fruitfly model of aging.
Anti-Aging Therapeutics 13   View the Table of Contents
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59. A Weighty Issue
Obesity and overweight are defined by Body Mass Index (BMI), the measure of body fat defined as body weight divided by the square of your height. Calculate your BMI by using the interactive U.S. National Heart, Lung, and Blood Institute's Body Mass Index calculator, at (look under "Health Assessment Tools," and select "Body Mass Index (BMI) Calculator") [provides both Metric and US measurements]. A BMI over 25 kg/m2 is defined as overweight, and a BMI of over 30 kg/m2 as obese.
Overweight and obesity can be life threatening, in that excess weight can result in:
• Cardiovascular disease
• Type 2 diabetes
• Cancer of the breast, colon, prostrate, endometrium, kidney and gallbladder
• more...
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