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Testosterone Raises Insulin Sensitivity

Posted Jul 19 2013 10:08pm

Giving testosterone to men with type 2 diabetes who are deficient in the hormone improved their insulin sensitivity, reports researchers from the University of Buffalo (New York, USA).  Paresh Dandona and colleagues conducted a randomized controlled trial of 81 men with type 2 diabetes.  Men were randomized to treatment with testosterone or placebo for 6 months. At baseline, those with hypogonadism had a higher body mass index (BMI) and a higher fat mass than those who didn't have low testosterone.  The team found that hypogonadal men with type 2 diabetes had significantly lower insulin sensitivity than those who did not have hypogonadism; further, that association remained even when controlling for weight and age (P=0.017). As well, free testosterone rose dramatically (4.1 nmol/L to 12.4 nmol/L), while placebo subjects had no significant changes in this parameter. Commenting that there was a "dramatic" 25% increase in insulin sensitivity … after these men took testosterone for 6 months,” the study authors note total lean body mass increased significantly for testosterone patients while fat mass significantly diminished in this group.

Dhindsa SS, et al. "Testosterone replacement decreases insulin resistance in hypogonadal men with type 2 diabetes" [Abstract OR22-1.]  Presented at ENDO 2013 (Annual Meeting of The Endocrine Society), June 19, 2013.

  
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Estimated to affect 125 million people worldwide, psoriasis is a chronic inflammatory condition affecting the immune system that commonly manifests in the form of thick, red, scaly patches on the skin.

Researchers from Harvard Medical School (Massachusetts, USA) found that the risk of coronary disease is almost 30% greater in psoriasis patients, and stroke risk exceeded the rate of the general population by 12%. The risk did not vary by severity of psoriasis, as patients with moderate and severe disease had a similar prevalence of heart disease and stroke. Separately, a Copenhagen University (Denmark) team studied nearly 50,000 patients who had experienced their first heart attack between 2002 and 2006, following the 462 patients with psoriasis for an average of 19.5 months and the 48,935 controls for an average of 22 months. The team found that heart attack patients with psoriasis were 26% more likely to die from cardiovascular disease, or suffer from recurrent heart attacks or strokes, and were 18% more likely to die from all causes than those without the inflammatory skin disease.

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