Health knowledge made personal
Join this community!
› Share page:
Go
Search posts:

Testosterone May Exert Benefits for Heart Failure

Posted May 07 2012 11:26am
Posted on 2012-05-07 06:00:00 in Cardio-Vascular | Hormone Replacement Therapy | Testosterone |

Testosterone supplementation may help improve exercise capacity and metabolic factors in patients with heart failure.  Justin Ezekowitz, from the University of Alberta (Canada), and colleagues completed a meta-analysis of four small, randomized, placebo-controlled trials involving a total of198 patients (84% male, mean age 67 years), with the majority of the patients (71%) having experienced ischemic heart failure.  The data showed that testosterone therapy associated with 16% to 23% relative improvements in walking distance and peak oxygen consumption. Specifically, on average, patients on testosterone walked 54 meters (16.7%) longer on the 6-minute walk test and 46.7 meters (15.9%) longer on the incremental shuttle walk test. Peak oxygen consumption (VO2) improved by 2.70 mL/kg/min (22.7%).  Although there were no effects on left ventricular ejection fraction, the percentage of patients who improved at least on New York Heart Association class was greater with testosterone (35% versus 9.8%).  The researchers noted that there were no major safety concerns, but acknowledged the small sample sizes and short lengths of follow-up.  The study authors conclude that: "Given the unmet clinical needs, testosterone appears to be a promising therapy to improve functional capacity in [heart failure] patients."

Mustafa Toma, Finlay A. McAlister, Erin E. Coglianese, Venketesan Vidi, Samip Vasaiwala, Justin A. Ezekowitz, et al.  “Testosterone Supplementation in Heart Failure: A Meta-Analysis.”  Circ Heart Fail., April 17, 2012.

  
Omega-3 fatty acids may improve cognitive functioning, presumably by increasing cerebral blood flow.
Testosterone supplementation improves walking, oxygen consumption, fasting glucose, and insulin, in patients with heart failure.
People with a history of mental illness are more likely to also have a chronic health condition, such as heart disease or diabetes.
People who sleep six hours or less are at increased risk having a greater body mass index (BMI).
Foods high in fiber provide good protection against cardiovascular disease, with the effect particularly pronounced among women.
Among men, one to two alcoholic drinks a day associates with lower risk of all-cause mortality, as well as cardiovascular death risk.
Eating tree nuts helps to lower body weight and body mass index, while improving cholesterol levels and markers of inflammation.
Shrinking of the hippocampal region of the brain occurs with age and may be caused by the cumulative effect of genetic factors.
Increased amount of phthalates circulating in blood may double a person's diabetes risk.
People who consume a greater quantity and variety of fruits and vegetables may cut their risk of diabetes by up to 21%.
Anti-Aging Therapeutics 13   View the Table of Contents
  Order the Book
  Order the eBook Anti-Aging Forum MLDP Anti-aging jobs Join A4M
263. Coffee Clutch
Don’t underestimate the humble cup of coffee. A European team reports that a daily cup of coffee helps to minimize the oxidative damage to DNA. Enrolling 38 men and women for a controlled intervention trial where each subject consumed 800 ml of paper-filtered coffee or water daily over 5 days. The researchers found that coffee reduced the oxidative damage to DNA, as measured by a decreased formation of oxidized purines, by 12.3%.

Among the most frequently consumed beverages worldwide, coffee is rich in antioxidants, with one cup providing 350 mg of phenolic compounds...
 
Post a comment
Write a comment:

Related Searches