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Testosterone May Exert Benefits for Heart Failure

Posted May 07 2012 11:26am
Posted on 2012-05-07 06:00:00 in Cardio-Vascular | Hormone Replacement Therapy | Testosterone |

Testosterone supplementation may help improve exercise capacity and metabolic factors in patients with heart failure.  Justin Ezekowitz, from the University of Alberta (Canada), and colleagues completed a meta-analysis of four small, randomized, placebo-controlled trials involving a total of198 patients (84% male, mean age 67 years), with the majority of the patients (71%) having experienced ischemic heart failure.  The data showed that testosterone therapy associated with 16% to 23% relative improvements in walking distance and peak oxygen consumption. Specifically, on average, patients on testosterone walked 54 meters (16.7%) longer on the 6-minute walk test and 46.7 meters (15.9%) longer on the incremental shuttle walk test. Peak oxygen consumption (VO2) improved by 2.70 mL/kg/min (22.7%).  Although there were no effects on left ventricular ejection fraction, the percentage of patients who improved at least on New York Heart Association class was greater with testosterone (35% versus 9.8%).  The researchers noted that there were no major safety concerns, but acknowledged the small sample sizes and short lengths of follow-up.  The study authors conclude that: "Given the unmet clinical needs, testosterone appears to be a promising therapy to improve functional capacity in [heart failure] patients."

Mustafa Toma, Finlay A. McAlister, Erin E. Coglianese, Venketesan Vidi, Samip Vasaiwala, Justin A. Ezekowitz, et al.  “Testosterone Supplementation in Heart Failure: A Meta-Analysis.”  Circ Heart Fail., April 17, 2012.

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263. Coffee Clutch
Don’t underestimate the humble cup of coffee. A European team reports that a daily cup of coffee helps to minimize the oxidative damage to DNA. Enrolling 38 men and women for a controlled intervention trial where each subject consumed 800 ml of paper-filtered coffee or water daily over 5 days. The researchers found that coffee reduced the oxidative damage to DNA, as measured by a decreased formation of oxidized purines, by 12.3%.

Among the most frequently consumed beverages worldwide, coffee is rich in antioxidants, with one cup providing 350 mg of phenolic compounds...
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