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Sugar Feeds Cancers

Posted Sep 05 2013 10:13pm

Previously, scientists have observed that people with Metabolic Syndrome – a condition characterized by central obesity, hypertension, and adverse glucose and insulin metabolism – are at an increased risk for certain cancers.  Using a fruit fly model, Ross L. Cagan, from the Ichan  School of Medicine at Mount Sinai (New York, USA), and colleagues have demonstrated that sugar activates oncogenes in the tumor, and also promoted tumor cell-specific insulin sensitivity by increasing the activity of the canonical signaling pathway.  The study authors submit that this feed-forward circuit may be targeted with “rationally applied drug combinations, we demonstrate the potential of combinatorial drug intervention to treat diet-enhanced malignant tumors.”

Susumu Hirabayashi, Thomas J. Baranski, Ross L. Cagan.  “Transformed Drosophila Cells Evade Diet-Mediated Insulin Resistance through Wingless Signaling.”  Cell; 154(3) pp. 664 – 675; 1 August 2013.

  
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Anti-Aging Forum MLDP Join A4M
Tip #192 - Stay Connected
Researchers from the University of Chicago (Illinois, USA) report that social isolation may be detrimental to both mental and physical health. The team analyzed data from the National Social Life, Health, and Aging Project, a nationwide US study involving 3,000 men and women, ages 57 to 85 years. They arrived at three key findings regarding the relationships between health and different types of isolation:

• The researchers found that the most socially connected older adults are three times as likely to report very good or excellent health compared to those who are least connected, regardless of whether they feel isolated.

• The team found that older adults who feel least isolated are five times as likely to report very good or excellent health as those who feel most isolated, regardless of their actual level of social connectedness.

• They determined that social disconnectedness is not related to mental health unless it brings feelings of loneliness and isolation.

Separately, Rush University Medical Center (Illinois, USA) researchers studied 906 older men and women, testing their motor functions (including grip, pinch strength, balance, and walking) and surveying their social activity, for a period of 5 years. Those study participants with less social activity were found to have a more rapid rate of motor function decline. Specifically, the team found that every one-point decrease in social activity corresponded to an increase in functional aging of 5 years, translating to a 40% higher risk of death and 65% higher risk of disability.

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