Too much sugar can set people down a pathway to heart failure, according to a study from researchers at The University of Texas Health Science Center at Houston (Texas, USA). Heinrich Taegtmeyer and colleagues report that a single small molecule, the glucose metabolite glucose 6-phosphate (G6P), causes stress to the heart that changes the muscle proteins and induces poor pump function leading to heart failure, as demonstrated by an animal model as well in tissue taken from patients at the Texas Heart Institute. In that G6P can accumulate from eating too much starch and/or sugar, the study authors “implicate a critical role for G6P in load-induced mTOR activation and [endoplasmic reticulum] stress,” proposing that: “glucose metabolic changes precede and regulate functional (and possibly also structural) remodeling of the heart.”
Sen S, Kundu BK, Wu HC, Hashmi SS, Guthrie P, Locke Taegtmeyer H, et al. “Glucose Regulation of Load-Induced mTOR Signaling and ER Stress in Mammalian Heart.” J Am Heart Assoc. 2013 May 17;2(3):e004796.
Testosterone gel improves performance on a specific cognitive task, among postmenopausal women with normal cognitive function.
Vitamin C may exert beneficial effects against exercise-induced bronchoconstriction.
A cup of hot cocoa may help to control inflammation-related diseases such as diabetes, suggests an animal study.
Exposure to low doses of the synthetic compound bisphenol A (BPA) is linked to increased risk of prostate cancer in human stem cells.
Metal-oxide nanofiber based chemiresistive gas sensors offer greater usability for real-time breath tests on smart phones or tablet PCs in the near future.
In heart muscle that is stressed by hypertension or other diseases, sugar overload may promote heart failure.
Fifteen-minute walks taken after meals help to curb blood sugar spikes.
A large-scale international genetic study confirms a causal association between low levels of vitamin D and hypertension (high blood pressure).
Bexarotene reverses memory deficits, in an Alzheimer's disease mouse model.
Cognition and arterial aging both may benefit from daily supplements of curcumin.
A group of researchers from Israel claim to have established an upper safe limit for vitamin D, the so-called sunshine vitamin.
Naturopathic therapies in conjunction with usual care may reduce a person’s risk factors for heart disease.
Heart failure costs are projected to more than double in the next 20 years, as the US population ages and the incidence of the condition climbs.
Elevated hair cortisol levels over time may correlate to an increased risk of cardiovascular disease.
Easily distressed individuals may be at higher risk of heart disease.
Long-term exposure to fine particles of traffic pollution may increase a person’s risk of heart disease.
A high heart rate may be an independent risk factor for mortality, among fit men.
A diet rich in antioxidants may reduce a woman’s risk of heart failure by 42%.
Stroke and subclinical markers of vascular disease may be predicative of those older patients with type 2 diabetes who may develop cognitive decline.
Diets laden with fried and sweet foods, processed and red meats refined grains, and high-fat dairy products reduce a person's likelihood of achieving older ages
Tip #187 - Milk The Benefits
Dairy and dairy products have been studied extensively for their promising health benefits:
• Combat Heart Disease & Stroke: University of Reading (United Kingdom) researchers studied findings from 324 studies of milk consumption as predictors of coronary heart disease (CHD), stroke and, diabetes. Data on milk consumption and cancer were based on the recent World Cancer Research Fund report. The team found that drinking milk can lessen the chances of dying from illnesses such as coronary heart disease and stroke by up to 15-20%. Separately, researchers from Bristol University (United Kingdom) studied data from the Carnegie (“Boyd Orr”) survey of diet and health in pre-war Britain. Tracking the lives and the dairy intake of 4,374 children between 1948 and 2005, the researchers found that 1,468 (34%) of them had died, and 378 of those deaths were caused by coronary heart disease and 121 were due to stroke. Not only did the study suggest that dairy rich diets in childhood do not contribute to heart problems later, the team found that higher childhood calcium intake was associated with lower stroke mortality. In addition, children who were in the group that had the highest calcium intake and dairy product consumption were found to have lower mortality rates than those in the lower intake groups.
• Maintain Cognitive Health: Researchers from the University of Oxford (United Kingdom) studied whether foods rich in Vitamin B-12 might counter homocysteine, a compound for which high levels are linked to an increased risk of heart disease and cognitive decline including Alzheimer's Disease. The team monitored 5,937 subjects in two age groups (47-49 years, and 71-74 years) participating in the Hordaland Homocysteine Study in Norway, surveying them for their daily food intake patterns. The team observed that those subjects with low B-12 levels suffered twice as much brain shrinkage as compared to those study participants with higher blood levels of the vitamin. The researchers observed two glasses of skim milk daily can help that raise plasma vitamin B-12 levels.