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Study Warns Of Potential Adverse Drug Interactions From Using New Blood Thinners

Posted Jun 02 2010 5:47am

Three new oral blood-thinning drugs nearing approval by the Food and Drug Administration are more convenient than the standard drug Coumadin® because they do not require monthly visits to adjust doses.

But the promising drugs also could be subject to dangerous interactions when taken alongside widely used prescription drugs, over-the-counter medicines such as aspirin and even herbal supplements such as St. John’s Wort, according to a Loyola University Health System study.

“Many unknowns remain as to how the new anticoagulants will behave in the real world patient population,” researchers conclude in a review article in the June issue of the International Journal of Clinical Practice.

While the new drugs offer “significant potential advantages,” their lack of extensive clinical experience “should not be underestimated,” researchers wrote.

Lead author is blood clot specialist Jeanine Walenga, PhD, a professor in the Cardiovascular Institute and departments of Thoracic and Cardiovascular Surgery and Pathology at Loyola University Chicago Stritch School of Medicine. Co-author is Cafer Adiguzel, MD, who completed a fellowship at Loyola.

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