Study shows treatment with a newly discovered drug could be useful in sensitizing tumor cells to therapeutic irradiation and potentially some chemotherapies
Scientists at St. Jude Children’s Research Hospital have shown that it might be possible to make tumor cells more sensitive to irradiation and some types of chemotherapy by treating them with a drug that cripples their ability to repair DNA damage caused by these therapies.
The St. Jude researchers demonstrated in the laboratory that a molecule called CP466722 rapidly blocks the ATM protein’s ability to orchestrate a series of biochemical events that culminate in the repair of DNA damaged by irradiation. The molecule exerted its effect in small quantities, and its effects rapidly ended after it was removed from cells, suggesting that such a treatment in humans would not have significant or long-term side effects, the researchers said.
Results of the study were published in the Sept. 15 issue of the journal Cancer Research.
Read more…..
Study shows treatment with a newly discovered drug could be useful in sensitizing tumor cells to therapeutic irradiation and potentially some chemotherapies
Scientists at St. Jude Children’s Research Hospital have shown that it might be possible to make tumor cells more sensitive to irradiation and some types of chemotherapy by treating them with a drug that cripples their ability to repair DNA damage caused by these therapies.
The St. Jude researchers demonstrated in the laboratory that a molecule called CP466722 rapidly blocks the ATM protein’s ability to orchestrate a series of biochemical events that culminate in the repair of DNA damaged by irradiation. The molecule exerted its effect in small quantities, and its effects rapidly ended after it was removed from cells, suggesting that such a treatment in humans would not have significant or long-term side effects, the researchers said.
Results of the study were published in the Sept. 15 issue of the journal Cancer Research.
Read more…..