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Study Finds Potential New Drug Therapy for Crohn’s Disease

Posted Oct 17 2012 9:20pm

Ustekinumab, an antibody proven to treat the skin condition psoriasis, has now shown positive results in decreasing the debilitating effects of Crohn’s Disease, according to researchers at the University of California San Diego, School of Medicine.  The study will appear in the October 18, 2012 issue of the New England Journal of Medicine (NEJM).

Results from the clinical trial showed ustekinumab (Stelara) increased clinical response and remission in patients suffering from moderate-to-severe Crohn’s Disease – a form of inflammatory bowel disease (IBD) that can lead to a variety of distressing symptoms, including diarrhea, intestinal bleeding and weight loss.   Serious complications such as bowel obstruction and abscesses can also occur.

“Our biggest challenge in treating patients with Crohn’s Disease is managing patients whose bodies are resistant to tumor necrosis factor (TNF) inhibitors such as Remicade, Humira and Cimzia,” said Sanborn, MD, principal investigator and chief of the Division of Gastroenterology at the UC San Diego School of Medicine.  “Ustekinumab blocks two proteins that cause inflammation, interleukin 12 and 23.  This finding is a significant first step towards a new treatment option for these patients.”


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