Still No Truce in the Stem-Cell Wars…Why (INDUCED PLURIPOTENT!!) Adult Cells Won’t End the Stem-Cell Wars –
Posted Feb 08 2010 12:00am
SO much confusing info (or perhaps, misinformation). Let me try to explain this…
Still No Truce in the Stem-Cell Wars
A new study finds serious problems with stem cells produced from adult cells. (they are referring to induced pluripotent stem cells – dg)
By Sharon Begley | Newsweek Web Exclusive Feb 11, 2010
“Embryonic” and “senescent” aren’t supposed to go together any more than “good” and “grief” or other oxymorons, which is why biologist Robert Lanza was “devastated” when he saw what was happening with the human stem cells he and colleagues were trying to grow. Like hundreds of other stem-cell scientists, they had been intrigued and energized by the 2007 discovery that adult cells can be regressed back to an embryonic state simply by inserting four genes into them. The discovery, by scientists at Kyoto University and the University of Wisconsin-Madison, seemed to promise a way out of the bitter debates over embryonic-stem-cell research: rather than using human embryos as a source of stem cells, produce them from adult cells.
Like cells from days-old embryos, the resulting have the ability to differentiate into any of 220 kinds of human cells, from neurons to retinal cells to pancreatic cells.
…btw, a number of adult stem cells have been found that can differentiate into any of 220 kinds of human cells, from neurons to retinal cells to pancreatic cells.- dg
Their promise was so great that when last March that he was lifting the ban on the use of federal money for research on human embryonic stem cells, critics on the right were apoplectic: iPS cells, they said, made such a move scientifically unjustified. Even President George W. Bush’s bioethics council cited the promise of iPS cells in ).
Lanza, the chief scientific officer at , and colleagues shared the optimism about iPS cells. They were trying to grow various types of cells from the iPS cells. It went fine at first, with the iPS cells differentiating into blood, vascular, and retinal cells as intended, the scientists are reporting today in . But things went south fast. Compared with specialized cells produced from the 25 lines of stem cells derived from embryos, those from the eight populations of iPS cells in the study had significantly higher rates of death through a mechanism called apoptosis (which is basically a suicide program within the cells), higher rates of aging (senescence), and severely lower rates of growth. The retinal cells and blood-vessel cells in particular were about as sprightly as cells ready for a nursing home, and lost their crucial ability to continue dividing…
Let’s be clear. Induced pluripotent stem cells are derived from adult cells. Adult cells are cells from a human that is not an embryo. They include virtually any cells, but they DO NOT include stem cells. For example; one of the best sources of skin cells used to generate induced pluripotent stem cells are those skin cells taken from the foreskin of a non-embryo.
Put another way; adult cells (including adult skin cells), as well as the induced pluripotent stem cells that may be generated from adult skin cells are NOT ADULT STEM CELLS.
INDUCED PLURIPOTANT STEM CELLS have problems (suicide triggers) – as detailed in this article.
EMBRYONIC STEM CELLS have problems (they cause tumors, have a proven failure to treat and are immersed in controversy) – as detailed in thousands of articles and trials and studies.
ADULT STEM CELLS on the other hand (also called REPAIR stem cells), have a proven history of safety and efficacy (meaning they work). They do not have suicide triggers, do not generate tumors, they do not have the controversy or failure record. ADULT or REPAIR STEM CELLS have been treating patients around the world for half a decade (40 years if you include stem cell rich bone marrow transplants). To learn more: http://repairstemcells.org/Resources/E-Newsletter.aspx