Health knowledge made personal
Join this community!
› Share page:
Go
Search posts:

Stem Cell Therapy Restores Vision

Posted Feb 05 2012 10:11pm
Posted on 2012-02-03 06:00:00 in Age-related Macular Degeneration | Stem Cell |

In the first-ever application of its kind, University of California/Los Angeles (UCLA; California, USA) scientists safely use human embryonic stem cells to treat macular degeneration in two patients. Steven Schwartz and colleagues also reports that some evidence suggested improvement in vision in this pilot study of patients with severe vision loss and two different forms of the disease (dry age-related macular degeneration, and a case of Stargardt's macular dystrophy).  The team conducted a controlled differentiation of the cells that resulted in a culture of retinal pigment epithelium cells that was 99% pure and, in animals, injection of the retinal cells was not associated with tumor formation or with any other safety issues.  The researchers injected 50,000 retinal pigment epithelium cells through a fine cannula into the subretinal space of one eye in each of the two patients and followed them for four months.  Both patients each ch had low-dose immunosuppression therapy starting a week before the procedure and continuing for six weeks afterward.  Whereas Both patients were legally blind prior to the procedure the researchers reported that he patient with macular degeneration improved from 21 letters on the Early Treatment Diabetic Retinopathy Study visual acuity chart to 33 letters at week two, stabilizing at 28 though the rest of the study period.  The patient with Stargardt's disease had clear improvements, and went from being unable to see hand movements at all to being able to see single finger movements. On the diabetic retinopathy acuity chart, she went from being able to read no letters to five.  Reporting that: [the stem-cell derived retinal pigment epithelium cells “showed no signs of hyperproliferation, tumorigenicity, ectopic tissue formation, or apparent rejection after 4 months,” the study authors urge that: “The future therapeutic goal will be to treat patients earlier in the disease processes, potentially increasing the likelihood of photoreceptor and central visual rescue.”

Steven D Schwartz, Jean-Pierre Hubschman, Gad Heilwell, Valentina Franco-Cardenas, Carolyn K Pan, Robert Lanza, et al.  “Embryonic stem cell trials for macular degeneration: a preliminary report.”  Lancet, 23 January 2012.

The best male marathon runners over age 65, and the best female marathon runners over age 45, continue to consistently improve their performance.
UCLA-led team safely uses human embryonic stem cells to treat macular degeneration.
First-of-its-kind study reports that indoor air in offices is an important source of worker exposure to potentially toxic substances.
Twenty percent of Americans ages 18+ experienced a diagnosable mental, behavioral, or emotional disorder in 2010.
In a lab animal model, vitamin D reduced the effects of aging in the eyes and improved the vision of older animals.
For the first time ever, stem cells from umbilical cords have been converted into other types of cells, paving the way for new treatment options for spinal cord
People affected by Alzheimer's disease are more likely to have low blood levels of vitamin E, as compared to people with normal cognitive function.
Virtual reality (VR)-enhanced exercise, that combine physical exercise with computer-simulated environments and interactive videogame features, yield a greater
Providing potent protection for eyes, grapes may help to slow or help prevent the onset of age-related macular degeneration (AMD).
Review paper confirms the multiple health benefits of consuming fruits, vegetables, and whole-grain foods.
Anti-Aging textbook Anti-Aging Forum MLDP Anti-aging jobs Join A4M ANTI-AGING TIP OF THE DAY
Lifelong Fitness Linked to Longevity
People who stay even moderately fit as they age may live longer than those who are out-of-shape. Researchers from the University of Otago ( New Zealand) studied 4,384 middle-aged and older adults whose fitness levels were assessed via exercise treadmill tests, then whom were followed for nine years. When the team separated the participants into five groups based on fitness levels, they found that one-quarter of the least-fit men and women had died during the study period, as compared to 13% of those who were slightly more in-shape.
 
Post a comment
Write a comment:

Related Searches