Genistein, a soybean compound, is a tyrosine kinase inhibitor that works by blocking the communication from a cell’s surface sensors to its interior. Found on a cell’s surface, these sensors tell the cell about its environment and also communicate with other cells. HIV uses some of these surface sensors to trick the cell to send signals inside. These signals change cell structure so that the virus can get inside and spread infection. Yuntao Wu, from George Mason University (Virginia, USA), and colleagues observe that genistein blocks the signal and stops HIV from finding a way inside the cell – holding promise as an effective treatment than the standard antiretroviral drug used to inhibit HIV. Commenting that: “Our results suggest that novel therapeutic strategies can be developed based on targeting cellular proteins involved in HIV-dependent signaling,” the study authors submit that: “This approach can interfere with HIV-mediated actin dynamics and inhibit HIV infection.”
Guo J, Xu X, Rasheed TK, Yoder A, Yu D, Liang H, Yi F, Hawley T, Jin T, Ling B, Wu Y. “Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells.” Retrovirology. 2013 Jun 19;10:62.
Levels of cortisol, the stress hormone, tend to be more stable in people with positive personalities.
Low hemoglobin levels in older adults may predict a long-term risk of developing dementia.
Abundant in the amino acid, l-Citrulline, watermelon juice can relieve sore muscles.
The blood cancer non-Hodgkin lymphoma occurs at greater incidence in relation to proximity near petroleum refineries and manufacturing plants.
Limited physical activity, a diet low in fruits and vegetables, and smoking are independently associated with risk of disability, among older men and women.
Genistein, a soybean compound, holds promise as an effective HIV treatment without the drug resistance issues faced by current therapies.
Irish researchers observe a slower rate of cognitive decline among elderly patients taking angiotensin-converting enzyme (ACE) inhibitors for blood pressure con
Sponge-like material, which expands and contracts in response to blood sugar levels, releases insulin contained in its core, as the body needs it.
Chinese men who practiced tai chi, a form of mind-body exercise, were less likely to die over a five-year period, as compared to sedentary men.
Low Vitamin D levels may increase a person’s risk of physical limitations, among older men and women.
University of Michigan (US) team discovers that BanLec, a compound in bananas, binds to key HIV-1 protein to inhibit disease transmission
Tip #192 - Stay Connected
Researchers from the University of Chicago (Illinois, USA) report that social isolation may be detrimental to both mental and physical health. The team analyzed data from the National Social Life, Health, and Aging Project, a nationwide US study involving 3,000 men and women, ages 57 to 85 years. They arrived at three key findings regarding the relationships between health and different types of isolation:
• The researchers found that the most socially connected older adults are three times as likely to report very good or excellent health compared to those who are least connected, regardless of whether they feel isolated.
• The team found that older adults who feel least isolated are five times as likely to report very good or excellent health as those who feel most isolated, regardless of their actual level of social connectedness.
• They determined that social disconnectedness is not related to mental health unless it brings feelings of loneliness and isolation.
Separately, Rush University Medical Center (Illinois, USA) researchers studied 906 older men and women, testing their motor functions (including grip, pinch strength, balance, and walking) and surveying their social activity, for a period of 5 years. Those study participants with less social activity were found to have a more rapid rate of motor function decline. Specifically, the team found that every one-point decrease in social activity corresponded to an increase in functional aging of 5 years, translating to a 40% higher risk of death and 65% higher risk of disability.