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Software for Modeling Tumor Delivery and Penetration of Antibody-Toxin Anti-Cancer Conjugates

Posted Jun 12 2012 8:00pm

Description of Invention:
Available for licensing is software for modeling permeability and concentration of intravenously administered antibody anti-cancer agent conjugates in solid tumor. The models can be used to determine optimal dosing regimen of a therapeutic in a particular cancer type. Thirty factors that affect delivery rates and efficiencies are analyzed as variables in generating the models.

Applications:
  • Drug Design
  • Combination Therapy
  • Personalized Medicine


Advantages:
  • Accurate permeability modeling of anti-cancer therapeutics
  • Personalized Medicine


Development Status:
  • Early-stage
  • Pre-clinical


Inventors:
Byungkook Lee (NCI)
Youngshang Pak (Pusan National University)
Ira H Pastan (NCI)


Patent Status:
HHS, Reference No. E-060-2012/0

Software — Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Fujimori K, et al. [ PMID 2362198 ]
  2. Jain RK. [ PMID 11259838 ]
  3. Thurber GM, et al. [ PMID 18541331 ]
  4. Li Y, et al. [ PMID 21569804 ]
  5. Drug delivery model simulations. [ http://www.accelereyes.com/examples/drug_delivery_model ]
  6. Pak Y, et al. [ PMID 22562466 ]


Collaborative Research Opportunity:
The NCI, CCR, Laboratory of Molecular Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize targeted delivery of anti-cancer agents in solid tumors. For collaboration opportunities, please contact John Hewes, Ph.D. at hewesj@mail.nih.gov .


For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
Fax: 301-402-0220


Ref No: 2451

Updated: 06/2012

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