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Smart Phone Monitors Blood Sugar

Posted Jul 15 2013 10:07pm

The first wearable artificial pancreas platform based on a smart phone has passed early feasibility tests in real-world settings.   Boris Kovatchev, from the University of Virginia (Virginia, USA), and colleagues have devised the Diabetes Assistant, consisting of a sensor placed under the skin that determines the interstitial glucose concentration, and transmits the information to a receiver. The information is processed and a signal is sent to the brain, which tells the pump how much insulin to give.  A continuous glucose monitoring/pump system was placed on each subject and connected to a smart phone device. The patient operated the system via the Diabetes Assistant user interface in open-loop mode for the first 14 hours of study. Then, they switched to closed-loop monitoring for another 28 hours. The system was tested among 20 subjects with type 1 diabetes in real-world settings – where participants wore the device while conducting routine daily activities, exercising, going to restaurants, staying in hotels, etc.  There were no serious adverse effects and no system failures.  The researchers comment that: “The investigational closed-loop system worked correctly 98% of the total possible time from admission to discharge,” demonstrating that: “we now have a good way to control overnight delivery of insulin from minute to minute, cutting down on episodes of hypoglycemia.”

Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM, et al.  “Feasibility of Outpatient Fully Integrated Closed-Loop Control: First studies of wearable artificial pancreas.”  Diabetes Care. 2013 Jul;36(7):1851-1858.

  
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Tip #189 - Slim Down to Live Longer
Body Mass Index (BMI) is the ratio between height and weight. The number indicates whether a person is underweight, overweight, or within a normal weight range. Individuals with a BMI of 25.0 or greater are considered overweight and those with a BMI of 30.0 or greater are considered obese. Increased BMI is an established risk factor for several causes of death including ischemic heart disease, stroke, and certain cancers.

Researchers from the University of Oxford (United Kingdom) reported that a BMI above the normal range is associated with an increased risk of death. The team reviewed data from 57 prospective studies involving a total of 894,576 patients in western Europe and North America as part of the Prospective Studies Collaboration. Mortality was about 30% higher for each additional 5 kg/m2, and primarily was correlated to 40% increased risk for vascular disease and 60 to 120% raised risks for diabetic, renal, and hepatic diseases, as well as 10% increased risk of neoplastic death and a 20% increased risk of death from respiratory causes. The researchers explain that: “"By avoiding a further increase from 28 kg/m2 to 32 kg/m2, a typical person in early middle age would gain about two years of life expectancy. Alternatively, by avoiding an increase from 24 kg/m2 to 32 kg/m2, a young adult would on average gain about three extra years of life."

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