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Silica-Coated Nanodiamonds for Imaging and the Delivery of Therapeutic Agents

Posted Feb 20 2013 7:00pm

Description of Invention:
NIH investigators invented a robust and easily implemented method of synthesizing silica-coated nanodiamonds for imaging and therapeutic applications. A patent estate covering these methods is offered for licensing to commercial entities. The method generally includes coating nanodiamonds with a silica precursor, e.g., tetraethylorthosilicate (TEOS), inside liposomes. The liposomes are then removed to yield a final product that is stable, monodisperse, and easy to functionalize.

Applications:
  • Imaging
  • Drug delivery


Advantages:
  • Small size
  • Physiologically inert carrier
  • Monodisperse
  • Stable in aqueous solution
  • Readily functionalized


Development Status:
Prototype

Inventors:
Ambika Bumb (NHLBI)
Susanta K Sarkar (NHLBI)
Martin W Brechbiel (NCI)
Keir C Neuman (NHLBI)


Patent Status:
HHS, Reference No. E-175-2012/0
US, Application No. 61/672,996 filed 18 Jul 2012


Related Technologies:
US, Application No. 61/711,702 filed 09 Oct 2012, Reference No. E-261-2012/0


Relevant Publication:
  1. Yu SJ, et al. [ PMID 16351080 ]
  2. Wilson RM. [ doi 10.1063/PT.3.1204 ]
  3. Chow EK, et al. [ PMID 21389265 ]
  4. Krueger A. [ PMID 18033700 ]


Collaborative Research Opportunity:
The NHLBI Laboratory of Single Molecule Biophysics is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize fluorescent nanodiamonds for use as in vivo and in vitro optical tracking probes. For collaboration opportunities, please contact Keir C. Neuman, Ph.D. at neumankc@mail.nih.gov or 301-496-3376.


For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
Fax: 301-402-0220


Ref No: 2533

Updated: 02/2013

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