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Sesame oil exhibits additive effect on nifedipine and modulates oxidative stress and electrolytes in hypertensive patients

Posted Mar 17 2010 12:00am

The objective of the study was to investigate the effect of sesame oil, as sole edible oil, in hypertensive patients who were on medication with nifedipine, a calcium channel blocker. A sample of 396 hypertensive patients (aged 58 ± 3.8 years; 215 men and 181 women) participated in this study.

Forty patients were treated only with nifedipine while three hundred and fifty-six patients were treated with nifedipine and instructed to use sesame oil in place of other edible oils for 60 days.

The consumption of sesame oil remarkably reduced the (systolic and diastolic blood pressure from 166 ± 4.2 and 101 ± 3.1 to 134.2 ± 3.4 and 84.6 ± 3.0, respectively) blood pressure. The dosage of the drug also reduced, as there was a fall in blood pressure during sesame oil consumption.

Plasma levels of sodium decreased while potassium and chloride increased significantly. Lipid peroxidation (thiobarbituric acid reactive substances) level significantly decreased while activities of enzymic (superoxide dismutase, glutathione peroxidase and catalase) and concentrations of non-enzymic antioxidants (vitamin C, vitamin E, β-carotene and reduced glutathione) increased in nifedipine-sesame oil group.

Nifedipine group showed a significant reduction in blood pressure, lipid peroxidation and improvement in reduced glutathione, however, the values are significantly lower than nifedipine-sesame oil group.

These results suggest that dietary substitution of sesame oil, in nifedipine-taking hypertensive patients, has an additive effect in the reduction of blood pressure and plays an important role in the modulation of electrolytes and in the reduction of lipid peroxidation and elevation of antioxidants.

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