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Sensitive Antibody-based Assay for the Measurement of c-Met Concentration Shed in Bodily Fluids Useful in the Diagnosis and Prog

Posted May 30 2012 8:00pm

Description of Invention:
This invention described and claimed in these patent applications provide for methods and assays which may be used to diagnose and follow the progression of cancers associated with c-Met expression. The data supporting this application suggests that c-Met expression may be an appropriate biomarker in certain types of cancer. In particular, the applications describe a sensitive assay useful for monitoring levels of c-Met shed in the urine or blood. The assay was developed using commercially available reagents. The applications contain data, derived from patient samples, supporting the clinical utility of the assay. In particular, the data shows the use of the assay to detect levels of shed c-Met in patients with bladder cancer, renal cancers and prostate cancer. Data showing the applicability of the assay for glioblastoma was derived using murine models of cancer for glioblastoma. Data showing the applicability of the assay for breast cancer, melanoma and prostate cancer was derived using various human cell line model systems.

HGF/met signaling has been most widely studied in settings related to cancer. It has been demonstrated to have a role in metastasis and angiogenesis. In addition to cancer, HGF activity has also been linked, through its role in apoptosis, to Alzheimer’s disease and cardiovascular disease.

Pathirage G Dharmawardana (Athauda) (NCI)
Donald P Bottaro (NCI)
Teresa L Burgess (Amgen Inc.)

Patent Status:
HHS, Reference No. E-261-2005/0
HHS, Reference No. E-261-2005/1
US, , Patent No. 7,964,365, Issued 21 Jun 2011
US, Application No. 13/053,560 filed 22 Mar 2011

Relevant Publication:
  1. These applications have not been published. The investigators presented their work in a poster session at the AACR Meeting April 16-20, 2005 ( Abstract 2788 ). At this time there are no other publications related to this work. [ Abstract 2788 ]

Collaborative Research Opportunity:
The National Cancer Institute, Urologic Oncology Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize HGF/c-Met signaling as it relates to tissue repair and regeneration, cancer, and other diseases. Please contact Brian W. Bailey, Ph.D. at (301) 451-2158 or for more information.

For Licensing Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Phone: 301-435-4478
Fax: 301-402-0220

Ref No: 1342

Updated: 05/2012

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