Selenium and the Methionine Sulfoxide Reductase System
Posted Nov 11 2009 10:03pm
By Derek B. Oien and Jackob Moskovitz
Abstract:
Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice, on the expression and function of Msr-related proteins are examined and (MsrA)discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA / mice are presented and discussed.
Abstract:
Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice, on the expression and function of Msr-related proteins are examined and (MsrA)discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA
/ mice are presented and discussed.
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