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SBU Researcher and Colleagues Unravel Genetic Blueprint Of Bacteria Causing Lyme Disease

Posted Oct 21 2010 8:22pm

Benjamin Luft, M.D., Professor of Medicine, Stony Brook University Medical Center, and a team of medical researchers have determined the genetic blueprint of 13 strains of the bacteria that cause Lyme disease. The finding is crucial to advancing research on Lyme disease, the most frequent tick-borne infection in North America and Europe, and may lead to better diagnostics and a vaccine. Dr. Luft presented the research results at an October 11 meeting in Washington, D.C., at the Institute of Medicine, an arm of the National Academy of Sciences. The study is reported in the early online edition of the Journal of Bacteriology.

Borrelia burgdorferi is the causative agent of Lyme disease. The first complete genome sequence of one strain of B. burgdorferi more than 10 years ago has helped researchers understand the pathogenesis of the disease. However, this understanding was limited with only a single genome sequence on one strain completed. By determining all genome sequences of B. burgdorferi, the researchers are providing a foundation for novel detection of Lyme disease, diagnostic approaches and prevention strategies. The timing is critical, as disease occurrence has become widespread over the past decade throughout the United States and part of Europe.

“By characterizing every gene in the Lyme disease agents family, we have a blueprint of every possible characteristic of the organism,” says Dr. Luft, senior author on the study. “This is the building block to developing more accurate and effective diagnostic tests, therapeutic agents and vaccines.

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