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Salt Consumption May Fuel Autoimmune Diseases

Posted Mar 25 2013 10:21pm
Posted on March 25, 2013, 6 a.m. in Autoimmune Diet

There has been a marked increase in the incidence of autoimmune diseases in the past half-century, and many public health experts speculate that this rise cannot be explained solely by genetic factors – rather that diet and lifestyle may be involved.  An international team of researchers, led by Markus Kleinewietfeld, from Yale University (Connecticut, USA), and colleagues completed cell culture experiments showing that increased sodium chloride can lead to dramatic induction of aggressive immune cells, known as Th17. In mice in which an experimental autoimmune condition mimicking multiple sclerosis was elicited, the team observed that these autoreactive Th17 cells exert a pivotal role in the pathogenesis of multiple sclerosis. Further, the number of these Th17 cells increased dramatically under a high-salt diet. The study authors conclude that: “Increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.”

Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. “Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.”  Nature. 2013 Mar 6.

  
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Anti-Aging Forum MLDP Join A4M
Tip #138 - Unlock the Genetics of Longevity
Telomeres are the endcaps on chromosomes, and telomeric shortening is thought to govern the number of times a cell can divide. In white blood cells (leukocytes), telomere shortening is used as a marker of biological age. King’s College London (United Kingdom) researchers studied 2,401 twins, tracking their physical activity level, lifestyle habits, and examined the length of the telomeres in the subjects’ white blood cells (leukocytes).The team confirmed that telomere length decreased with age; men and women who were less physically active in their leisure time had shorter leukocyte telomeres than those who were more active. The mean difference in leukocyte telomere length between the most active subjects (who performed an average of 199 minutes of physical activity per week) versus the least active subjects (16 minutes of physical activity per week) was 200 nucleotides. This translated to mean that “the most active subjects had telomeres the same length as sedentary individuals up to 10 years younger, on average.”

Regular physical activity helps improve your overall health and fitness, and reduces your risk for many chronic diseases. Men and women ages 18 to 64 years need at least:

• 2 hours and 30 minutes (150 minutes) of moderate-intensity aerobic activity (i.e., brisk walking) every week; and muscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest, shoulders, and arms).

OR:
• 1 hour and 15 minutes (75 minutes) of vigorous-intensity aerobic activity (i.e., jogging or running) every week; and muscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest, shoulders, and arms).

OR:
• An equivalent mix of moderate- and vigorous-intensity aerobic activity and muscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest, shoulders, and arms).

Not only is it best to spread your activity out during the week, but you can break it up into smaller chunks of time during the day. As long as you're doing your activity at a moderate or vigorous effort for at least 10 minutes at a time. Consult an anti-aging physician to construct a regimen that is appropriate for your medical needs.
 
 
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