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Role of Resveratrol for Hearing & Cognition

Posted Mar 17 2013 10:09pm

In that their previous studies have reported the efficacy of resveratrol, a grape compound noted for its antioxidant and anti-inflammatory properties, to reduce temporary threshold shifts and decrease cochlear hair cell damage following noise exposure, Michael D. Seidman, from  Henry Ford Hospital (Michigan, USA), and colleagues examined the potential protective mechanism of resveratrol with regard to its effect on bioinflammation – the body’s response to  injury and which may be associated with many aging-related concerns from Alzheimer’s Disease to cancer.    The study was designed to identify the potential protective mechanism of resveratrol following noise exposure by measuring its effect on cyclooxygenase-2 (or COX-2, key to the inflammatory process) protein expression and formation of reactive oxygen species, which plays an important role in cell signaling and homeostasis. The data revealed that acoustic overstimulation causes a time-depended, up-regulation of COX-2 protein expression. And, resveratrol significantly reduces reactive oxygen species formation, inhibits COX-2 expression and reduces noise-induced hearing loss following noise exposure in rats.  Observing that: “by giving animals resveratrol, we can reduce the amount of hearing and cognitive decline," the study authors submit that their findings suggest that resveratrol may exert a protective effect from noise-induced hearing loss by the inhibition of COX-2 expression and reactive oxygen species formation. 

Seidman MD, Tang W, Bai VU, Ahmad N, Jiang H, Media J, Patel N, Rubin CJ, Standring RT.  “Resveratrol Decreases Noise-Induced Cyclooxygenase-2 Expression in the Rat Cochlea.”  Otolaryngol Head Neck Surg. 2013 Feb 4.

  
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Anti-Aging Forum MLDP Join A4M
Tip #136 - Live Healthy, Live Longer
A number of studies validate lifestyle and other modifiable factors to promote a long and healthy lifespan:

• Cambridge University (United Kingdom) researchers report that healthy lifestyle choices can extend lifespan by 14 years. In a study of 20,000 men and women, ages 45 to 79, conducted for 13 years, Kay-Tee Khaw and colleagues found that those study subjects with the lowest number of healthy behaviors were four-times more likely to die, most notably from cardiovascular disease. Specifically, the team found that study participants with the lowest healthy lifestyle scores had the same risk of dying as someone with the highest healthy lifestyle scores who was 14 years older. The lifestyle change with the biggest benefit was smoking cessation, associated with an 80% improvement in lifespan. The second most significant change was increased consumption of fresh fruits and vegetables. Thirdly, moderate drinking; and fourthly, staying physically active, rounded out the four most beneficial lifestyle choices to extend lifespan.
• US Centers for Disease Control and Prevention (Atlanta, Georgia USA) researchers studied data collected on 23,153 German men and women, ages 35 to 65 years, who participated in the European Prospective Investigation Into Cancer and Nutrition-Potsdam study. The team found that four lifestyle factors -- namely never smoking, having a body mass index (BMI) of 30 or less, exercising 3.5 hours a week and eating a healthy diet – slashed the risk of cardiovascular disease, diabetes, and cancer by a staggering 80%.

Lifestyle choices including not smoking, eating fresh foods, engaging in regular exercise, minimizing psychological stress, and drinking in moderation are basic tenets of the anti-aging lifestyle. By embracing these concepts, not only might we extend how long we may live, but how well. A prolonged healthspan -- the length of time that we are able to live productively and independently – is, in many ways, as important as an extended lifespan.
 
 
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