Health knowledge made personal
Join this community!
› Share page:
Search posts:

Role of Resveratrol for Hearing & Cognition

Posted Mar 17 2013 10:09pm

In that their previous studies have reported the efficacy of resveratrol, a grape compound noted for its antioxidant and anti-inflammatory properties, to reduce temporary threshold shifts and decrease cochlear hair cell damage following noise exposure, Michael D. Seidman, from  Henry Ford Hospital (Michigan, USA), and colleagues examined the potential protective mechanism of resveratrol with regard to its effect on bioinflammation – the body’s response to  injury and which may be associated with many aging-related concerns from Alzheimer’s Disease to cancer.    The study was designed to identify the potential protective mechanism of resveratrol following noise exposure by measuring its effect on cyclooxygenase-2 (or COX-2, key to the inflammatory process) protein expression and formation of reactive oxygen species, which plays an important role in cell signaling and homeostasis. The data revealed that acoustic overstimulation causes a time-depended, up-regulation of COX-2 protein expression. And, resveratrol significantly reduces reactive oxygen species formation, inhibits COX-2 expression and reduces noise-induced hearing loss following noise exposure in rats.  Observing that: “by giving animals resveratrol, we can reduce the amount of hearing and cognitive decline," the study authors submit that their findings suggest that resveratrol may exert a protective effect from noise-induced hearing loss by the inhibition of COX-2 expression and reactive oxygen species formation. 

Seidman MD, Tang W, Bai VU, Ahmad N, Jiang H, Media J, Patel N, Rubin CJ, Standring RT.  “Resveratrol Decreases Noise-Induced Cyclooxygenase-2 Expression in the Rat Cochlea.”  Otolaryngol Head Neck Surg. 2013 Feb 4.

A diet rich in fish-source omega-3 fatty acids exerts an antihypertensive effect.
Men and women ages 65+ could boost their cognitive function by learning to use Facebook.
Consumption of green tea may reduce a woman’s risk of developing breast cancer.
Resveratrol, an antioxidant substance found abundantly in red grapes and red wine, may have the potential to protect against hearing loss and cognitive decline.
A large study of 500,000 older adults followed for about 12 years reveals that as coffee drinking increases, the risk of death decreases.
Adolescents and young adults with a range of cardiometabolic risk factors have an increased risk of dying before they turn 55.
From Australia to Great Britain, researcher teams confirm that the more a person sits, the greater the risk of chronic diseases.
Individuals with shortened telomeres are at an increased risk of contracting colds, in a laboratory setting.
A Mediterranean-style diet may curtail the risks of heart attack, stroke, and cardiovascular-related death
Elevated levels of ozone and fine particulate matter in ambient air correlate to increased incidence of out-of-hospital cardiac arrests.
Analysis across large-scale studies suggests that baseline high-sensitivity C-reactive protein associates with development of age-related macular degeneration.
Among healthy adults, simple changes in diet can be effective in reducing inflammation in as little as six weeks.
A type of meditation, known as mindfulness-based stress reduction, helps to relieve the inflammation response seen in arthritis, inflammatory bowel disease, and
Fifteen new genetic regions associated with coronary artery disease have been identified by a large, international consortium of scientists.
Oregon State University (US) team reveals the biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system
Anthocyanins, antioxidant pigments found in fruit and vegetables, have been found to improve the blood lipid profile of people with high cholesterol.
Following a simple meditation program can help to reduce loneliness and reduce the expression of inflammatory genes.
Rich in a variety of antioxidants, cocoa and green tea extracts help to reduce markers of oxidative stress and inflammation, in overweight men and women.
Kirtan Kriya Meditation (KKM), a type of yoga, reduces inflammation – thereby curbing the stress response of caregivers to those affected by chronic diseases.
Epigallocatechin gallate (EGCG), an antioxidant compound found abundantly in green tea, helps to improve blood pressure, and blood sugar levels.
Anti-Aging Forum MLDP Join A4M
Tip #136 - Live Healthy, Live Longer
A number of studies validate lifestyle and other modifiable factors to promote a long and healthy lifespan:

• Cambridge University (United Kingdom) researchers report that healthy lifestyle choices can extend lifespan by 14 years. In a study of 20,000 men and women, ages 45 to 79, conducted for 13 years, Kay-Tee Khaw and colleagues found that those study subjects with the lowest number of healthy behaviors were four-times more likely to die, most notably from cardiovascular disease. Specifically, the team found that study participants with the lowest healthy lifestyle scores had the same risk of dying as someone with the highest healthy lifestyle scores who was 14 years older. The lifestyle change with the biggest benefit was smoking cessation, associated with an 80% improvement in lifespan. The second most significant change was increased consumption of fresh fruits and vegetables. Thirdly, moderate drinking; and fourthly, staying physically active, rounded out the four most beneficial lifestyle choices to extend lifespan.
• US Centers for Disease Control and Prevention (Atlanta, Georgia USA) researchers studied data collected on 23,153 German men and women, ages 35 to 65 years, who participated in the European Prospective Investigation Into Cancer and Nutrition-Potsdam study. The team found that four lifestyle factors -- namely never smoking, having a body mass index (BMI) of 30 or less, exercising 3.5 hours a week and eating a healthy diet – slashed the risk of cardiovascular disease, diabetes, and cancer by a staggering 80%.

Lifestyle choices including not smoking, eating fresh foods, engaging in regular exercise, minimizing psychological stress, and drinking in moderation are basic tenets of the anti-aging lifestyle. By embracing these concepts, not only might we extend how long we may live, but how well. A prolonged healthspan -- the length of time that we are able to live productively and independently – is, in many ways, as important as an extended lifespan.
Post a comment
Write a comment:

Related Searches